UniProt data
UniProt name: FCGRN_HUMAN (P55899)
Gene name: FCGRT; Synonyms=FCRN
Organism: Homo sapiens (Human).
Function: Binds to the Fc region of monomeric immunoglobulins gamma. Mediates the uptake of IgG from milk. Possible role in transfer of immunoglobulin G from mother to fetus.
Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Transmembrane domains:
- 298-321, 24 AA, Helical. {ECO:0000255}.
Sequence: 365 AA
CATM prediction
The sequence of FCGRN_HUMAN returned 5 potential models
The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.
| # | Sequence and interface | d | θ | Z' | ω' | Score |
|---|---|---|---|---|---|---|
| 300 310 320 + | + | + | |
(Å) | (°) | (Å) | (°) | ||
| Model 1 | KSSVLVVGIVIGVLLLTAAAVGGALLWRRM | 6.7 | -46.1° | 3.6 | 37.0 | -35.4 |
| Model 2 | KSSVLVVGIVIGVLLLTAAAVGGALLWRRM | 7.1 | -51.2° | 4.4 | 39.9 | -16.0 |
| Model 3 | KSSVLVVGIVIGVLLLTAAAVGGALLWRRM | 7.2 | -55.0° | 0.9 | 50.3 | -15.4 |
| Model 4 | KSSVLVVGIVIGVLLLTAAAVGGALLWRRM | 7.4 | -49.1° | 3.9 | 37.9 | -14.5 |
| Model 5 | KSSVLVVGIVIGVLLLTAAAVGGALLWRRM | 7.3 | -54.9° | 0.3 | 45.1 | -6.1 |
Click on the model number to visualize its details below.
MODEL 1 DETAILS
Precited structure:
Click on the image to enlarge
Download model 1 structure: PDB, PyMOL session
List of hydrogen bonds:
| Donor | Acceptor | Distance |
|---|---|---|
| B, 314, ALA, HA | A, 313, ALA, O | 2.72Å |
| B, 317, GLY, HA1 | A, 314, ALA, O | 2.76Å |
| A, 314, ALA, HA | B, 313, ALA, O | 2.72Å |
| A, 317, GLY, HA1 | B, 314, ALA, O | 2.76Å |
