Cadherin-12

UniProt data

UniProt name: CAD12_HUMAN (P55289)

Gene name: CDH12

Organism: Homo sapiens (Human).

Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

Subcellular location: Cell membrane; Single-pass type I membrane protein.

Transmembrane domains:

  1. 610-637, 28 AA, Helical. {ECO:0000255}.

Sequence: 794 AA

10 20 30 40 50 60 MLTRNCLSLL LWVLFDGGLL TPLQPQPQQT LATEPRENVI HLPGQRSHFQ RVKRGWVWNQ 70 80 90 100 110 120 FFVLEEYVGS EPQYVGKLHS DLDKGEGTVK YTLSGDGAGT VFTIDETTGD IHAIRSLDRE 130 140 150 160 170 180 EKPFYTLRAQ AVDIETRKPL EPESEFIIKV QDINDNEPKF LDGPYVATVP EMSPVGAYVL 190 200 210 220 230 240 QVKATDADDP TYGNSARVVY SILQGQPYFS IDPKTGVIRT ALPNMDREVK EQYQVLIQAK 250 260 270 280 290 300 DMGGQLGGLA GTTIVNITLT DVNDNPPRFP KSIFHLKVPE SSPIGSAIGR IRAVDPDFGQ 310 320 330 340 350 360 NAEIEYNIVP GDGGNLFDIV TDEDTQEGVI KLKKPLDFET KKAYTFKVEA SNLHLDHRFH 370 380 390 400 410 420 SAGPFKDTAT VKISVLDVDE PPVFSKPLYT MEVYEDTPVG TIIGAVTAQD LDVGSSAVRY 430 440 450 460 470 480 FIDWKSDGDS YFTIDGNEGT IATNELLDRE STAQYNFSII ASKVSNPLLT SKVNILINVL 490 500 510 520 530 540 DVNEFPPEIS VPYETAVCEN AKPGQIIQIV SAADRDLSPA GQQFSFRLSP EAAIKPNFTV 550 560 570 580 590 600 RDFRNNTAGI ETRRNGYSRR QQELYFLPVV IEDSSYPVQS STNTMTIRVC RCDSDGTILS 610 620 630 640 650 660 CNVEAIFLPV GLSTGALIAI LLCIVILLAI VVLYVALRRQ KKKDTLMTSK EDIRDNVIHY 670 680 690 700 710 720 DDEGGGEEDT QAFDIGALRN PKVIEENKIR RDIKPDSLCL PRQRPPMEDN TDIRDFIHQR 730 740 750 760 770 780 LQENDVDPTA PPYDSLATYA YEGSGSVAES LSSIDSLTTE ADQDYDYLTD WGPRFKVLAD 790 MFGEEESYNP DKVT

CATM prediction

The sequence of CAD12_HUMAN returned 7 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
     610       620       630       6
   |    +    |    +    |    +    |		 (Å) (°) (Å) (°)  
Model 1 FLAVGLSTGALIAILLCIVILLAIVVLYVALRRQ 6.8 -43.9° 1.8 45.3 -20.4
Model 2 FLAVGLSTGALIAILLCIVILLAIVVLYVALRRQ 7.2 -28.0° 0.8 59.0 -17.9
Model 3 FLAVGLSTGALIAILLCIVILLAIVVLYVALRRQ 6.5 -43.1° 5.4 59.7 -15.3
Model 4 FLAVGLSTGALIAILLCIVILLAIVVLYVALRRQ 6.7 -55.0° 2.4 47.9 -8.8
Model 5 FLAVGLSTGALIAILLCIVILLAIVVLYVALRRQ 7.2 -50.9° 0.2 44.8 -7.6
Model 6 FLAVGLSTGALIAILLCIVILLAIVVLYVALRRQ 7.2 -47.9° -0.0 37.8 -5.4
Model 7 FLAVGLSTGALIAILLCIVILLAIVVLYVALRRQ 6.7 -55.0° 0.9 50.0 -5.2
Prolines* FLPVGLSTGALIAILLCIVILLAIVVLYVALRRQ          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 612, LEU, HA A, 611, GLY, O 2.96Å
B, 615, GLY, HA1 A, 612, LEU, O 2.77Å
B, 616, ALA, HA A, 615, GLY, O 3.13Å
A, 612, LEU, HA B, 611, GLY, O 2.96Å
A, 615, GLY, HA1 B, 612, LEU, O 2.77Å
A, 616, ALA, HA B, 615, GLY, O 3.13Å