Cadherin-8

UniProt data

UniProt name: CADH8_HUMAN (P55286)

Gene name: CDH8

Organism: Homo sapiens (Human).

Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

Subcellular location: Cell membrane; Single-pass type I membrane protein.

Transmembrane domains:

  1. 622-642, 21 AA, Helical. {ECO:0000255}.

Sequence: 799 AA

10 20 30 40 50 60 MPERLAEMLL DLWTPLIILW ITLPPCIYMA PMNQSQVLMS GSPLELNSLG EEQRILNRSK 70 80 90 100 110 120 RGWVWNQMFV LEEFSGPEPI LVGRLHTDLD PGSKKIKYIL SGDGAGTIFQ INDVTGDIHA 130 140 150 160 170 180 IKRLDREEKA EYTLTAQAVD WETSKPLEPP SEFIIKVQDI NDNAPEFLNG PYHATVPEMS 190 200 210 220 230 240 ILGTSVTNVT ATDADDPVYG NSAKLVYSIL EGQPYFSIEP ETAIIKTALP NMDREAKEEY 250 260 270 280 290 300 LVVIQAKDMG GHSGGLSGTT TLTVTLTDVN DNPPKFAQSL YHFSVPEDVV LGTAIGRVKA 310 320 330 340 350 360 NDQDIGENAQ SSYDIIDGDG TALFEITSDA QAQDGIIRLR KPLDFETKKS YTLKVEAANV 370 380 390 400 410 420 HIDPRFSGRG PFKDTATVKI VVEDADEPPV FSSPTYLLEV HENAALNSVI GQVTARDPDI 430 440 450 460 470 480 TSSPIRFSID RHTDLERQFN INADDGKITL ATPLDRELSV WHNITIIATE IRNHSQISRV 490 500 510 520 530 540 PVAIKVLDVN DNAPEFASEY EAFLCENGKP GQVIQTVSAM DKDDPKNGHY FLYSLLPEMV 550 560 570 580 590 600 NNPNFTIKKN EDNSLSILAK HNGFNRQKQE VYLLPIIISD SGNPPLSSTS TLTIRVCGCS 610 620 630 640 650 660 NDGVVQSCNV EAYVLPIGLS MGALIAILAC IILLLVIVVL FVTLRRHKNE PLIIKDDEDV 670 680 690 700 710 720 RENIIRYDDE GGGEEDTEAF DIATLQNPDG INGFLPRKDI KPDLQFMPRQ GLAPVPNGVD 730 740 750 760 770 780 VDEFINVRLH EADNDPTAPP YDSIQIYGYE GRGSVAGSLS SLESTTSDSD QNFDYLSDWG 790 PRFKRLGELY SVGESDKET

CATM prediction

The sequence of CADH8_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
   620       630       640   
 |    +    |    +    |    +		 (Å) (°) (Å) (°)  
Model 1 LSMGALIAILACIILLLVIVVLFVTLR 7.3 -47.0° 6.0 45.0 -10.3

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 623, ALA, HA A, 622, GLY, O 3.25Å
A, 623, ALA, HA B, 622, GLY, O 3.25Å