Ephrin type-A receptor 5

UniProt data

UniProt name: EPHA5_HUMAN (P54756)

Gene name: EPHA5; Synonyms=BSK, EHK1, HEK7, TYRO4

Organism: Homo sapiens (Human).

Function: Receptor tyrosine kinase which binds promiscuously GPI- anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino- hippocampal and hippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. In addition to its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose- stimulated insulin secretion (By similarity). {ECO:0000250}.

Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P54757}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, axon {ECO:0000250|UniProtKB:P54757}. Cell projection, dendrite {ECO:0000250|UniProtKB:P54756}.

Transmembrane domains:

  1. 574-594, 21 AA, Helical. {ECO:0000255}.

Sequence: 1037 AA

10 20 30 40 50 60 MRGSGPRGAG RRRPPSGGGD TPITPASLAG CYSAPRRAPL WTCLLLCAAL RTLLASPSNE 70 80 90 100 110 120 VNLLDSRTVM GDLGWIAFPK NGWEEIGEVD ENYAPIHTYQ VCKVMEQNQN NWLLTSWISN 130 140 150 160 170 180 EGASRIFIEL KFTLRDCNSL PGGLGTCKET FNMYYFESDD QNGRNIKENQ YIKIDTIAAD 190 200 210 220 230 240 ESFTELDLGD RVMKLNTEVR DVGPLSKKGF YLAFQDVGAC IALVSVRVYY KKCPSVVRHL 250 260 270 280 290 300 AVFPDTITGA DSSQLLEVSG SCVNHSVTDE PPKMHCSAEG EWLVPIGKCM CKAGYEEKNG 310 320 330 340 350 360 TCQVCRPGFF KASPHIQSCG KCPPHSYTHE EASTSCVCEK DYFRRESDPP TMACTRPPSA 370 380 390 400 410 420 PRNAISNVNE TSVFLEWIPP ADTGGRKDVS YYIACKKCNS HAGVCEECGG HVRYLPRQSG 430 440 450 460 470 480 LKNTSVMMVD LLAHTNYTFE IEAVNGVSDL SPGARQYVSV NVTTNQAAPS PVTNVKKGKI 490 500 510 520 530 540 AKNSISLSWQ EPDRPNGIIL EYEIKYFEKD QETSYTIIKS KETTITAEGL KPASVYVFQI 550 560 570 580 590 600 RARTAAGYGV FSRRFEFETT PVFAASSDQS QIPVIAVSVT VGVILLAVVI GVLLSGSCCE 610 620 630 640 650 660 CGCGRASSLC AVAHPSLIWR CGYSKAKQDP EEEKMHFHNG HIKLPGVRTY IDPHTYEDPN 670 680 690 700 710 720 QAVHEFAKEI EASCITIERV IGAGEFGEVC SGRLKLPGKR ELPVAIKTLK VGYTEKQRRD 730 740 750 760 770 780 FLGEASIMGQ FDHPNIIHLE GVVTKSKPVM IVTEYMENGS LDTFLKKNDG QFTVIQLVGM 790 800 810 820 830 840 LRGISAGMKY LSDMGYVHRD LAARNILINS NLVCKVSDFG LSRVLEDDPE AAYTTRGGKI 850 860 870 880 890 900 PIRWTAPEAI AFRKFTSASD VWSYGIVMWE VVSYGERPYW EMTNQDVIKA VEEGYRLPSP 910 920 930 940 950 960 MDCPAALYQL MLDCWQKERN SRPKFDEIVN MLDKLIRNPS SLKTLVNASC RVSNLLAEHS 970 980 990 1000 1010 1020 PLGSGAYRSV GEWLEAIKMG RYTEIFMENG YSSMDAVAQV TLEDLRRLGV TLVGHQKKIM 1030 NSLQEMKVQL VNGMVPL

CATM prediction

The sequence of EPHA5_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
           580       590     
    +    |    +    |    +  		 (Å) (°) (Å) (°)  
Model 1 QIAVIAVSVTVGVILLAVVIGVLLSGS 6.9 -45.9° 2.7 47.0 -24.5
Prolines* QIPVIAVSVTVGVILLAVVIGVLLSGS          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 588, VAL, HA A, 587, ALA, O 2.90Å
B, 591, GLY, HA1 A, 588, VAL, O 2.87Å
B, 592, VAL, HA A, 591, GLY, O 3.49Å
A, 588, VAL, HA B, 587, ALA, O 2.90Å
A, 591, GLY, HA1 B, 588, VAL, O 2.87Å
A, 592, VAL, HA B, 591, GLY, O 3.49Å