Sodium/potassium-transporting ATPase subunit beta-3

UniProt data

UniProt name: AT1B3_HUMAN (P54709)

Gene name: ATP1B3

Organism: Homo sapiens (Human).

Function: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known.

Subcellular location: Cell membrane {ECO:0000269|PubMed:17081065}; Single-pass type II membrane protein {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Transmembrane domains:

  1. 36-56, 21 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.

Sequence: 279 AA

10 20 30 40 50 60 MTKNEKKSLN QSLAEWKLFI YNPTTGEFLG RTAKSWGLIL LFYLVFYGFL AALFSFTMWV 70 80 90 100 110 120 MLQTLNDEVP KYRDQIPSPG LMVFPKPVTA LEYTFSRSDP TSYAGYIEDL KKFLKPYTLE 130 140 150 160 170 180 EQKNLTVCPD GALFEQKGPV YVACQFPISL LQACSGMNDP DFGYSQGNPC ILVKMNRIIG 190 200 210 220 230 240 LKPEGVPRID CVSKNEDIPN VAVYPHNGMI DLKYFPYYGK KLHVGYLQPL VAVQVSFAPN 250 260 270 NTGKEVTVEC KIDGSANLKS QDDRDKFLGR VMFKITARA

CATM prediction

The sequence of AT1B3_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
         40        50        
  +    |    +    |    +    		 (Å) (°) (Å) (°)  
Model 1 AKSWGLILLFYLVFYGFLAALFSFTMW 7.2 -55.1° 0.9 49.6 -4.6

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 48, GLY, HA1 A, 45, VAL, O 3.36Å
B, 49, PHE, HA A, 48, GLY, O 3.44Å
A, 48, GLY, HA1 B, 45, VAL, O 3.36Å
A, 49, PHE, HA B, 48, GLY, O 3.44Å