Voltage-dependent calcium channel subunit alpha-2/delta-1

UniProt data

UniProt name: CA2D1_HUMAN (P54289)

Gene name: CACNA2D1; Synonyms=CACNL2A, CCHL2A, MHS3

Organism: Homo sapiens (Human).

Function: The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling (By similarity). {ECO:0000250}.

Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 1074-1094, 21 AA, Helical. {ECO:0000255}.

Sequence: 1103 AA

10 20 30 40 50 60 MAAGCLLALT LTLFQSLLIG PSSEEPFPSA VTIKSWVDKM QEDLVTLAKT ASGVNQLVDI 70 80 90 100 110 120 YEKYQDLYTV EPNNARQLVE IAARDIEKLL SNRSKALVRL ALEAEKVQAA HQWREDFASN 130 140 150 160 170 180 EVVYYNAKDD LDPEKNDSEP GSQRIKPVFI EDANFGRQIS YQHAAVHIPT DIYEGSTIVL 190 200 210 220 230 240 NELNWTSALD EVFKKNREED PSLLWQVFGS ATGLARYYPA SPWVDNSRTP NKIDLYDVRR 250 260 270 280 290 300 RPWYIQGAAS PKDMLILVDV SGSVSGLTLK LIRTSVSEML ETLSDDDFVN VASFNSNAQD 310 320 330 340 350 360 VSCFQHLVQA NVRNKKVLKD AVNNITAKGI TDYKKGFSFA FEQLLNYNVS RANCNKIIML 370 380 390 400 410 420 FTDGGEERAQ EIFNKYNKDK KVRVFTFSVG QHNYDRGPIQ WMACENKGYY YEIPSIGAIR 430 440 450 460 470 480 INTQEYLDVL GRPMVLAGDK AKQVQWTNVY LDALELGLVI TGTLPVFNIT GQFENKTNLK 490 500 510 520 530 540 NQLILGVMGV DVSLEDIKRL TPRFTLCPNG YYFAIDPNGY VLLHPNLQPK PIGVGIPTIN 550 560 570 580 590 600 LRKRRPNIQN PKSQEPVTLD FLDAELENDI KVEIRNKMID GESGEKTFRT LVKSQDERYI 610 620 630 640 650 660 DKGNRTYTWT PVNGTDYSLA LVLPTYSFYY IKAKLEETIT QARYSETLKP DNFEESGYTF 670 680 690 700 710 720 IAPRDYCNDL KISDNNTEFL LNFNEFIDRK TPNNPSCNAD LINRVLLDAG FTNELVQNYW 730 740 750 760 770 780 SKQKNIKGVK ARFVVTDGGI TRVYPKEAGE NWQENPETYE DSFYKRSLDN DNYVFTAPYF 790 800 810 820 830 840 NKSGPGAYES GIMVSKAVEI YIQGKLLKPA VVGIKIDVNS WIENFTKTSI RDPCAGPVCD 850 860 870 880 890 900 CKRNSDVMDC VILDDGGFLL MANHDDYTNQ IGRFFGEIDP SLMRHLVNIS VYAFNKSYDY 910 920 930 940 950 960 QSVCEPGAAP KQGAGHRSAY VPSVADILQI GWWATAAAWS ILQQFLLSLT FPRLLEAVEM 970 980 990 1000 1010 1020 EDDDFTASLS KQSCITEQTQ YFFDNDSKSF SGVLDCGNCS RIFHGEKLMN TNLIFIMVES 1030 1040 1050 1060 1070 1080 KGTCPCDTRL LIQAEQTSDG PNPCDMVKQP RYRKGPDVCF DNNVLEDYTD CGGVSGLNPS 1090 1100 LWYIIGIQFL LLWLVSGSTH RLL

CATM prediction

The sequence of CA2D1_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
           1080      1090    
    +    |    +    |    +  		 (Å) (°) (Å) (°)  
Model 1 CGGVSGLNASLWYIIGIQFLLLWLVSG 6.5 -43.0° 6.0 44.0 -6.2
Model 2 CGGVSGLNASLWYIIGIQFLLLWLVSG 7.0 +50.8° 3.9 71.8 -0.0
Prolines* CGGVSGLNPSLWYIIGIQFLLLWLVSG          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session