HRAS-like suppressor 3

UniProt data

UniProt name: HRSL3_HUMAN (P53816)

Gene name: PLA2G16; Synonyms=HRASLS3, HREV107

Organism: Homo sapiens (Human).

Function: Exhibits PLA1/2 activity, catalyzing the calcium- independent hydrolysis of acyl groups in various phosphatidylcholines (PC) and phosphatidylethanolamine (PE). For most substrates, PLA1 activity is much higher than PLA2 activity. Specifically catalyzes the release of fatty acids from phospholipids in adipose tissue (By similarity). N- and O- acylation activity is hardly detectable. Might decrease protein phosphatase 2A (PP2A) activity. {ECO:0000250, ECO:0000269|PubMed:17374643, ECO:0000269|PubMed:19615464}.

Subcellular location: Cytoplasm. Cytoplasm, perinuclear region {ECO:0000250}. Membrane; Single-pass membrane protein.

Transmembrane domains:

  1. 133-155, 23 AA, Helical. {ECO:0000255}.

Sequence: 162 AA

10 20 30 40 50 60 MRAPIPEPKP GDLIEIFRPF YRHWAIYVGD GYVVHLAPPS EVAGAGAASV MSALTDKAIV 70 80 90 100 110 120 KKELLYDVAG SDKYQVNNKH DDKYSPLPCS KIIQRAEELV GQEVLYKLTS ENCEHFVNEL 130 140 150 160 RYGVARSDQV RDVIIAASVA GMGLAAMSLI GVMFSRNKRQ KQ

CATM prediction

The sequence of HRSL3_HUMAN returned 3 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
  130       140       150      
|    +    |    +    |    +   		 (Å) (°) (Å) (°)  
Model 1 VRDVIIAASVAGMGLAAMSLIGVMFSRNK 6.7 -49.9° 2.9 46.7 -20.8
Model 2 VRDVIIAASVAGMGLAAMSLIGVMFSRNK 7.2 -44.1° 1.8 45.0 -15.2
Model 3 VRDVIIAASVAGMGLAAMSLIGVMFSRNK 7.4 -47.0° 2.2 45.0 -10.0

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 138, SER, HA A, 137, ALA, O 2.85Å
B, 141, GLY, HA1 A, 138, SER, O 2.86Å
A, 138, SER, HA B, 137, ALA, O 2.85Å
A, 141, GLY, HA1 B, 138, SER, O 2.86Å