Pituitary tumor-transforming gene 1 protein-interacting protein

UniProt data

UniProt name: PTTG_HUMAN (P53801)

Gene name: PTTG1IP; Synonyms=C21orf1, C21orf3

Organism: Homo sapiens (Human).

Function: May facilitate PTTG1 nuclear translocation.

Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:10781616}. Nucleus {ECO:0000269|PubMed:10781616}. Note=According to PubMed:10781616, it is found in the cytoplasm and the nucleus.

Transmembrane domains:

  1. 97-117, 21 AA, Helical. {ECO:0000255}.

Sequence: 180 AA

10 20 30 40 50 60 MAPGVARGPT PYWRLRLGGA ALLLLLIPVA AAQEPPGAAC SQNTNKTCEE CLKNVSCLWC 70 80 90 100 110 120 NTNKACLDYP VTSVLPPASL CKLSSARWGV CWVNFEALII TMSVVGGTLL LGIAICCCCC 130 140 150 160 170 CRRKRSRKPD RSEEKAMRER EERRIRQEER RAEMKTRHDE IRKKYGLFKE ENPYARFENN

CATM prediction

The sequence of PTTG_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
        100       110       1
 +    |    +    |    +    |		 (Å) (°) (Å) (°)  
Model 1 NFEALIITMSVVGGTLLLGIAICCCCC 7.3 -54.7° 2.4 48.0 -16.4
Model 2 NFEALIITMSVVGGTLLLGIAICCCCC 6.9 -54.0° 2.5 33.1 -1.6

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 109, LEU, HA A, 108, THR, O 3.46Å
B, 112, GLY, HA1 A, 109, LEU, O 3.23Å
A, 109, LEU, HA B, 108, THR, O 3.46Å
A, 112, GLY, HA1 B, 109, LEU, O 3.23Å