Plexin-A3

UniProt data

UniProt name: PLXA3_HUMAN (P51805)

Gene name: PLXNA3; Synonyms=PLXN4, SEX

Organism: Homo sapiens (Human).

Function: Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the migration of sympathetic neurons, but not of neural crest precursors. Required for normal dendrite spine morphology in pyramidal neurons. May play a role in regulating semaphorin-mediated programmed cell death in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.

Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.

Transmembrane domains:

  1. 1221-1241, 21 AA, Helical. {ECO:0000255}.

Sequence: 1871 AA

10 20 30 40 50 60 MPSVCLLLLL FLAVGGALGN RPFRAFVVTD TTLTHLAVHR VTGEVFVGAV NRVFKLAPNL 70 80 90 100 110 120 TELRAHVTGP VEDNARCYPP PSMRVCAHRL APVDNINKLL LIDYAARRLV ACGSIWQGIC 130 140 150 160 170 180 QFLRLDDLFK LGEPHHRKEH YLSGAQEPDS MAGVIVEQGQ GPSKLFVGTA VDGKSEYFPT 190 200 210 220 230 240 LSSRKLISDE DSADMFSLVY QDEFVSSQIK IPSDTLSLYP AFDIYYIYGF VSASFVYFLT 250 260 270 280 290 300 LQLDTQQTLL DTAGEKFFTS KIVRMCAGDS EFYSYVEFPI GCSWRGVEYR LVQSAHLAKP 310 320 330 340 350 360 GLLLAQALGV PADEDVLFTI FSQGQKNRAS PPRQTILCLF TLSNINAHIR RRIQSCYRGE 370 380 390 400 410 420 GTLALPWLLN KELPCINTPM QINGNFCGLV LNQPLGGLHV IEGLPLLADS TDGMASVAAY 430 440 450 460 470 480 TYRQHSVVFI GTRSGSLKKV RVDGFQDAHL YETVPVVDGS PILRDLLFSP DHRHIYLLSE 490 500 510 520 530 540 KQVSQLPVET CEQYQSCAAC LGSGDPHCGW CVLRHRCCRE GACLGASAPH GFAEELSKCV 550 560 570 580 590 600 QVRVRPNNVS VTSPGVQLTV TLHNVPDLSA GVSCAFEAAA ENEAVLLPSG ELLCPSPSLQ 610 620 630 640 650 660 ELRALTRGHG ATRTVRLQLL SKETGVRFAG ADFVFYNCSV LQSCMSCVGS PYPCHWCKYR 670 680 690 700 710 720 HTCTSRPHEC SFQEGRVHSP EGCPEILPSG DLLIPVGVMQ PLTLRAKNLP QPQSGQKNYE 730 740 750 760 770 780 CVVRVQGRQQ RVPAVRFNSS SVQCQNASYS YEGDEHGDTE LDFSVVWDGD FPIDKPPSFR 790 800 810 820 830 840 ALLYKCWAQR PSCGLCLKAD PRFNCGWCIS EHRCQLRTHC PAPKTNWMHL SQKGTRCSHP 850 860 870 880 890 900 RITQIHPLVG PKEGGTRVTI VGDNLGLLSR EVGLRVAGVR CNSIPAEYIS AERIVCEMEE 910 920 930 940 950 960 SLVPSPPPGP VELCVGDCSA DFRTQSEQVY SFVTPTFDQV SPSRGPASGG TRLTISGSSL 970 980 990 1000 1010 1020 DAGSRVTVTV RDSECQFVRR DAKAIVCISP LSTLGPSQAP ITLAIDRANI SSPGLIYTYT 1030 1040 1050 1060 1070 1080 QDPTVTRLEP TWSIINGSTA ITVSGTHLLT VQEPRVRAKY RGIETTNTCQ VINDTAMLCK 1090 1100 1110 1120 1130 1140 APGIFLGRPQ PRAQGEHPDE FGFLLDHVQT ARSLNRSSFT YYPDPSFEPL GPSGVLDVKP 1150 1160 1170 1180 1190 1200 GSHVVLKGKN LIPAAAGSSR LNYTVLIGGQ PCSLTVSDTQ LLCDSPSQTG RQPVMVLVGG 1210 1220 1230 1240 1250 1260 LEFWLGTLHI SAERALTLPA MMGLAAGGGL LLLAITAVLV AYKRKTQDAD RTLKRLQLQM 1270 1280 1290 1300 1310 1320 DNLESRVALE CKEAFAELQT DINELTNHMD EVQIPFLDYR TYAVRVLFPG IEAHPVLKEL 1330 1340 1350 1360 1370 1380 DTPPNVEKAL RLFGQLLHSR AFVLTFIHTL EAQSSFSMRD RGTVASLTMV ALQSRLDYAT 1390 1400 1410 1420 1430 1440 GLLKQLLADL IEKNLESKNH PKLLLRRTES VAEKMLTNWF TFLLHKFLKE CAGEPLFLLY 1450 1460 1470 1480 1490 1500 CAIKQQMEKG PIDAITGEAR YSLSEDKLIR QQIDYKTLTL HCVCPENEGS AQVPVKVLNC 1510 1520 1530 1540 1550 1560 DSITQAKDKL LDTVYKGIPY SQRPKAEDMD LEWRQGRMTR IILQDEDVTT KIECDWKRLN 1570 1580 1590 1600 1610 1620 SLAHYQVTDG SLVALVPKQV SAYNMANSFT FTRSLSRYES LLRTASSPDS LRSRAPMITP 1630 1640 1650 1660 1670 1680 DQETGTKLWH LVKNHDHADH REGDRGSKMV SEIYLTRLLA TKGTLQKFVD DLFETVFSTA 1690 1700 1710 1720 1730 1740 HRGSALPLAI KYMFDFLDEQ ADQRQISDPD VRHTWKSNCL PLRFWVNVIK NPQFVFDIHK 1750 1760 1770 1780 1790 1800 NSITDACLSV VAQTFMDSCS TSEHRLGKDS PSNKLLYAKD IPNYKSWVER YYRDIAKMAS 1810 1820 1830 1840 1850 1860 ISDQDMDAYL VEQSRLHASD FSVLSALNEL YFYVTKYRQE ILTALDRDAS CRKHKLRQKL 1870 EQIISLVSSD S

CATM prediction

The sequence of PLXA3_HUMAN returned 4 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
    1220      1230      1240 
  |    +    |    +    |    		 (Å) (°) (Å) (°)  
Model 1 LAAMMGLAAGGGLLLLAITAVLVAYKR 7.1 -26.0° 3.6 54.0 -22.3
Model 2 LAAMMGLAAGGGLLLLAITAVLVAYKR 6.9 -54.1° 2.6 32.8 -11.7
Model 3 LAAMMGLAAGGGLLLLAITAVLVAYKR 7.3 -53.3° 3.2 33.8 -8.2
Model 4 LAAMMGLAAGGGLLLLAITAVLVAYKR 7.1 -38.0° 5.7 34.0 -6.7
Prolines* LPAMMGLAAGGGLLLLAITAVLVAYKR          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session