UniProt data
UniProt name: APLP1_HUMAN (P51693)
Gene name: APLP1
Organism: Homo sapiens (Human).
Function: The gamma-CTF peptide, C30, is a potent enhancer of neuronal apoptosis. {ECO:0000250}.
Subcellular location: C30: Cytoplasm. Note=C-terminally processed in the Golgi complex.
Transmembrane domains:
- 581-603, 23 AA, Helical. {ECO:0000255}.
Sequence: 650 AA
10 20 30 40 50 60
MGPASPAARG LSRRPGQPPL PLLLPLLLLL LRAQPAIGSL AGGSPGAAEA PGSAQVAGLC
70 80 90 100 110 120
GRLTLHRDLR TGRWEPDPQR SRRCLRDPQR VLEYCRQMYP ELQIARVEQA TQAIPMERWC
130 140 150 160 170 180
GGSRSGSCAH PHHQVVPFRC LPGEFVSEAL LVPEGCRFLH QERMDQCESS TRRHQEAQEA
190 200 210 220 230 240
CSSQGLILHG SGMLLPCGSD RFRGVEYVCC PPPGTPDPSG TAVGDPSTRS WPPGSRVEGA
250 260 270 280 290 300
EDEEEEESFP QPVDDYFVEP PQAEEEEETV PPPSSHTLAV VGKVTPTPRP TDGVDIYFGM
310 320 330 340 350 360
PGEISEHEGF LRAKMDLEER RMRQINEVMR EWAMADNQSK NLPKADRQAL NEHFQSILQT
370 380 390 400 410 420
LEEQVSGERQ RLVETHATRV IALINDQRRA ALEGFLAALQ ADPPQAERVL LALRRYLRAE
430 440 450 460 470 480
QKEQRHTLRH YQHVAAVDPE KAQQMRFQVH THLQVIEERV NQSLGLLDQN PHLAQELRPQ
490 500 510 520 530 540
IQELLHSEHL GPSELEAPAP GGSSEDKGGL QPPDSKDDTP MTLPKGSTEQ DAASPEKEKM
550 560 570 580 590 600
NPLEQYERKV NASVPRGFPF HSSEIQRDEL APAGTGVSRE AVSGLLIMGA GGGSLIVLSM
610 620 630 640
LLLRRKKPYG AISHGVVEVD PMLTLEEQQL RELQRHGYEN PTYRFLEERP
CATM prediction
The sequence of APLP1_HUMAN returned 3 potential models
The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.
| # | Sequence and interface | d | θ | Z' | ω' | Score |
|---|---|---|---|---|---|---|
| 580 590 600 | + | + | + |
(Å) | (°) | (Å) | (°) | ||
| Model 1 | SREAVSGLLIMGAGGGSLIVLSMLLLRRK | 6.3 | -51.1° | 6.0 | 44.9 | -24.4 |
| Model 2 | SREAVSGLLIMGAGGGSLIVLSMLLLRRK | 6.7 | -40.0° | 4.0 | 38.3 | -20.6 |
| Model 3 | SREAVSGLLIMGAGGGSLIVLSMLLLRRK | 7.2 | -45.9° | 3.6 | 37.0 | -20.0 |
Click on the model number to visualize its details below.
MODEL 1 DETAILS
Precited structure:
Click on the image to enlarge
Download model 1 structure: PDB, PyMOL session
List of hydrogen bonds:
| Donor | Acceptor | Distance |
|---|---|---|
| B, 586, LEU, HA | A, 585, LEU, O | 3.44Å |
| B, 589, GLY, HA1 | A, 586, LEU, O | 2.59Å |
| B, 590, ALA, HA | A, 589, GLY, O | 2.35Å |
| B, 593, GLY, HA1 | A, 590, ALA, O | 3.10Å |
| A, 586, LEU, HA | B, 585, LEU, O | 3.44Å |
| A, 589, GLY, HA1 | B, 586, LEU, O | 2.59Å |
| A, 590, ALA, HA | B, 589, GLY, O | 2.35Å |
| A, 593, GLY, HA1 | B, 590, ALA, O | 3.10Å |
