Alpha-mannosidase 2x

UniProt data

UniProt name: MA2A2_HUMAN (P49641)

Gene name: MAN2A2; Synonyms=MANA2X

Organism: Homo sapiens (Human).

Function: Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway.

Subcellular location: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.

Transmembrane domains:

  1. 6-26, 21 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.

Sequence: 1150 AA

10 20 30 40 50 60 MKLKKQVTVC GAAIFCVAVF SLYLMLDRVQ HDPTRHQNGG NFPRSQISVL QNRIEQLEQL 70 80 90 100 110 120 LEENHEIISH IKDSVLELTA NAEGPPAMLP YYTVNGSWVV PPEPRPSFFS ISPQDCQFAL 130 140 150 160 170 180 GGRGQKPELQ MLTVSEELPF DNVDGGVWRQ GFDISYDPHD WDAEDLQVFV VPHSHNDPGW 190 200 210 220 230 240 IKTFDKYYTE QTQHILNSMV SKLQEDPRRR FLWAEVSFFA KWWDNINVQK RAAVRRLVGN 250 260 270 280 290 300 GQLEIATGGW VMPDEANSHY FALIDQLIEG HQWLERNLGA TPRSGWAVDP FGYSSTMPYL 310 320 330 340 350 360 LRRANLTSML IQRVHYAIKK HFAATHSLEF MWRQTWDSDS STDIFCHMMP FYSYDVPHTC 370 380 390 400 410 420 GPDPKICCQF DFKRLPGGRI NCPWKVPPRA ITEANVAERA ALLLDQYRKK SQLFRSNVLL 430 440 450 460 470 480 VPLGDDFRYD KPQEWDAQFF NYQRLFDFFN SRPNLHVQAQ FGTLSDYFDA LYKRTGVEPG 490 500 510 520 530 540 ARPPGFPVLS GDFFSYADRE DHYWTGYYTS RPFYKSLDRV LEAHLRGAEV LYSLAAAHAR 550 560 570 580 590 600 RSGLAGRYPL SDFTLLTEAR RTLGLFQHHD AITGTAKEAV VVDYGVRLLR SLVNLKQVII 610 620 630 640 650 660 HAAHYLVLGD KETYHFDPEA PFLQVDDTRL SHDALPERTV IQLDSSPRFV VLFNPLEQER 670 680 690 700 710 720 FSMVSLLVNS PRVRVLSEEG QPLAVQISAH WSSATEAVPD VYQVSVPVRL PALGLGVLQL 730 740 750 760 770 780 QLGLDGHRTL PSSVRIYLHG RQLSVSRHEA FPLRVIDSGT SDFALSNRYM QVWFSGLTGL 790 800 810 820 830 840 LKSIRRVDEE HEQQVDMQVL VYGTRTSKDK SGAYLFLPDG EAKPYVPKEP PVLRVTEGPF 850 860 870 880 890 900 FSEVVAYYEH IHQAVRLYNL PGVEGLSLDI SSLVDIRDYV NKELALHIHT DIDSQGIFFT 910 920 930 940 950 960 DLNGFQVQPR RYLKKLPLQA NFYPMPVMAY IQDAQKRLTL HTAQALGVSS LKDGQLEVIL 970 980 990 1000 1010 1020 DRRLMQDDNR GLGQGLKDNK RTCNRFRLLL ERRTVGSEVQ DSHSTSYPSL LSHLTSMYLN 1030 1040 1050 1060 1070 1080 APALALPVAR MQLPGPGLRS FHPLASSLPC DFHLLNLRTL QAEEDTLPSA ETALILHRKG 1090 1100 1110 1120 1130 1140 FDCGLEAKNL GFNCTTSQGK VALGSLFHGL DVVFLQPTSL TLLYPLASPS NSTDVYLEPM EIATFRLRLG

CATM prediction

The sequence of MA2A2_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
         10        20        
  +    |    +    |    +    		 (Å) (°) (Å) (°)  
Model 1 LKKQVTVCGAAIFCVAVFSLYLMLDRV 7.1 -51.0° 2.4 45.0 -9.5

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 8, THR, HA A, 7, VAL, O 3.19Å
B, 11, GLY, HA1 A, 8, THR, O 3.01Å
B, 23, TYR, HH A, 23, TYR, OH 2.13Å
A, 8, THR, HA B, 7, VAL, O 3.19Å
A, 11, GLY, HA1 B, 8, THR, O 3.01Å