Interferon alpha/beta receptor 2

UniProt data

UniProt name: INAR2_HUMAN (P48551)

Gene name: IFNAR2; Synonyms=IFNABR, IFNARB

Organism: Homo sapiens (Human).

Function: Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation (PubMed:26424569). Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1 (PubMed:8181059, PubMed:7665574, PubMed:7759950). Isoform 3 is a potent inhibitor of type I IFN receptor activity (PubMed:7759950). {ECO:0000269|PubMed:10049744, ECO:0000269|PubMed:11682488, ECO:0000269|PubMed:12105218, ECO:0000269|PubMed:26424569, ECO:0000269|PubMed:7665574, ECO:0000269|PubMed:7759950, ECO:0000269|PubMed:8181059}.

Subcellular location: Isoform 3: Secreted {ECO:0000269|PubMed:7759950, ECO:0000269|PubMed:8181059}.

Transmembrane domains:

  1. 244-264, 21 AA, Helical. {ECO:0000255}.

Sequence: 515 AA

10 20 30 40 50 60 MLLSQNAFIF RSLNLVLMVY ISLVFGISYD SPDYTDESCT FKISLRNFRS ILSWELKNHS 70 80 90 100 110 120 IVPTHYTLLY TIMSKPEDLK VVKNCANTTR SFCDLTDEWR STHEAYVTVL EGFSGNTTLF 130 140 150 160 170 180 SCSHNFWLAI DMSFEPPEFE IVGFTNHINV MVKFPSIVEE ELQFDLSLVI EEQSEGIVKK 190 200 210 220 230 240 HKPEIKGNMS GNFTYIIDKL IPNTNYCVSV YLEHSDEQAV IKSPLKCTLL PPGQESESAE 250 260 270 280 290 300 SAKIGGIITV FLIALVLTST IVTLKWIGYI CLRNSLPKVL NFHNFLAWPF PNLPPLEAMD 310 320 330 340 350 360 MVEVIYINRK KKVWDYNYDD ESDSDTEAAP RTSGGGYTMH GLTVRPLGQA SATSTESQLI 370 380 390 400 410 420 DPESEEEPDL PEVDVELPTM PKDSPQQLEL LSGPCERRKS PLQDPFPEED YSSTEGSGGR 430 440 450 460 470 480 ITFNVDLNSV FLRVLDDEDS DDLEAPLMLS SHLEEMVDPE DPDNVQSNHL LASGEGTQPT 490 500 510 FPSPSSEGLW SEDAPSDQSD TSESDVDLGD GYIMR

CATM prediction

The sequence of INAR2_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
           250       260     
    +    |    +    |    +  		 (Å) (°) (Å) (°)  
Model 1 SAKIGGIITVFLIALVLTSTIVTLKWI 7.0 -43.0° 5.5 34.0 -10.2
Model 2 SAKIGGIITVFLIALVLTSTIVTLKWI 7.1 -49.0° 2.9 32.0 -5.0

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session