Tumor necrosis factor ligand superfamily member 6

UniProt data

UniProt name: TNFL6_HUMAN (P48023)

Gene name: FASLG; Synonyms=APT1LG1, CD95L, FASL, TNFSF6

Organism: Homo sapiens (Human).

Function: The FasL intracellular domain (FasL ICD) cytoplasmic form induces gene transcription inhibition. {ECO:0000269|PubMed:17557115}.

Subcellular location: FasL intracellular domain: Nucleus. Note=The FasL ICD cytoplasmic form is translocated into the nucleus.

Transmembrane domains:

  1. 81-102, 22 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.

Sequence: 281 AA

10 20 30 40 50 60 MQQPFNYPYP QIYWVDSSAS SPWAPPGTVL PCPTSVPRRP GQRRPPPPPP PPPLPPPPPP 70 80 90 100 110 120 PPLPPLPLPP LKKRGNHSTG LCLLVMFFMV LVALVGLGLG MFQLFHLQKE LAELRESTSQ 130 140 150 160 170 180 MHTASSLEKQ IGHPSPPPEK KELRKVAHLT GKSNSRSMPL EWEDTYGIVL LSGVKYKKGG 190 200 210 220 230 240 LVINETGLYF VYSKVYFRGQ SCNNLPLSHK VYMRNSKYPQ DLVMMEGKMM SYCTTGQMWA 250 260 270 280 RSSYLGAVFN LTSADHLYVN VSELSLVNFE ESQTFFGLYK L

CATM prediction

The sequence of TNFL6_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
    80        90        100   
  |    +    |    +    |    +		 (Å) (°) (Å) (°)  
Model 1 STGLCLLVMFFMVLVALVGLGLGMFQLF 7.0 -53.1° 3.2 34.1 -21.7

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 93, ALA, HA A, 92, VAL, O 3.17Å
B, 96, GLY, HA1 A, 93, ALA, O 3.03Å
A, 93, ALA, HA B, 92, VAL, O 3.17Å
A, 96, GLY, HA1 B, 93, ALA, O 3.03Å