Cytochrome b-c1 complex subunit Rieske, mitochondrial

UniProt data

UniProt name: UCRI_HUMAN (P47985)

Gene name: UQCRFS1

Organism: Homo sapiens (Human).

Function: The transit peptide of the Rieske protein seems to form part of the bc1 complex and is considered to be the subunit 11/IX of that complex. {ECO:0000250}.

Subcellular location: Mitochondrion inner membrane; Single-pass membrane protein.

Transmembrane domains:

  1. 103-140, 38 AA, Helical. {ECO:0000250}.

Sequence: 274 AA

10 20 30 40 50 60 MLSVASRSGP FAPVLSATSR GVAGALRPLV QATVPATPEQ PVLDLKRPFL SRESLSGQAV 70 80 90 100 110 120 RRPLVASVGL NVPASVCYSH TDIKVPDFSE YRRLEVLDST KSSRESSEAR KGFSYLVTGV 130 140 150 160 170 180 TTVGVAYAAK NAVTQFVSSM SASADVLALA KIEIKLSDIP EGKNMAFKWR GKPLFVRHRT 190 200 210 220 230 240 QKEIEQEAAV ELSQLRDPQH DLDRVKKPEW VILIGVCTHL GCVPIANAGD FGGYYCPCHG 250 260 270 SHYDASGRIR LGPAPLNLEV PTYEFTSDDM VIVG

CATM prediction

The sequence of UCRI_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
  100       110       120       130       140 
|    +    |    +    |    +    |    +    |   		 (Å) (°) (Å) (°)  
Model 1 TKSSRESSEARKGFSYLVTGVTTVGVAYAAKNAVTQFVSSMSAS 7.4 -51.0° 3.3 48.1 -16.5
Model 2 TKSSRESSEARKGFSYLVTGVTTVGVAYAAKNAVTQFVSSMSAS 7.1 -40.0° 2.7 33.8 -5.5

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 116, LEU, HA A, 115, TYR, O 3.34Å
B, 119, GLY, HA1 A, 116, LEU, O 3.42Å
A, 115, TYR, HH B, 108, GLU, OE1 2.47Å
A, 116, LEU, HA B, 115, TYR, O 3.34Å
A, 119, GLY, HA1 B, 116, LEU, O 3.42Å
A, 127, TYR, HH B, 127, TYR, OH 2.07Å