UniProt data
UniProt name: KI3L2_HUMAN (P43630)
Gene name: KIR3DL2; Synonyms=CD158K, NKAT4
Organism: Homo sapiens (Human).
Function: Receptor on natural killer (NK) cells for HLA-A alleles. Inhibits the activity of NK cells thus preventing cell lysis.
Subcellular location: Cell membrane; Single-pass type I membrane protein.
Transmembrane domains:
- 341-360, 20 AA, Helical. {ECO:0000255}.
Sequence: 455 AA
10 20 30 40 50 60
MSLTVVSMAC VGFFLLQGAW PLMGGQDKPF LSARPSTVVP RGGHVALQCH YRRGFNNFML
70 80 90 100 110 120
YKEDRSHVPI FHGRIFQESF IMGPVTPAHA GTYRCRGSRP HSLTGWSAPS NPLVIMVTGN
130 140 150 160 170 180
HRKPSLLAHP GPLLKSGETV ILQCWSDVMF EHFFLHREGI SEDPSRLVGQ IHDGVSKANF
190 200 210 220 230 240
SIGPLMPVLA GTYRCYGSVP HSPYQLSAPS DPLDIVITGL YEKPSLSAQP GPTVQAGENV
250 260 270 280 290 300
TLSCSSWSSY DIYHLSREGE AHERRLRAVP KVNRTFQADF PLGPATHGGT YRCFGSFRAL
310 320 330 340 350 360
PCVWSNSSDP LLVSVTGNPS SSWPSPTEPS SKSGICRHLH VLIGTSVVIF LFILLLFFLL
370 380 390 400 410 420
YRWCSNKKNA AVMDQEPAGD RTVNRQDSDE QDPQEVTYAQ LDHCVFIQRK ISRPSQRPKT
430 440 450
PLTDTSVYTE LPNAEPRSKV VSCPRAPQSG LEGVF
CATM prediction
The sequence of KI3L2_HUMAN returned 1 potential models
The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.
| # | Sequence and interface | d | θ | Z' | ω' | Score |
|---|---|---|---|---|---|---|
| 340 350 360 | + | + | |
(Å) | (°) | (Å) | (°) | ||
| Model 1 | HLHVLIGTSVVIFLFILLLFFLLYRW | 7.4 | -51.0° | 3.3 | 48.0 | -0.1 |
Click on the model number to visualize its details below.
MODEL 1 DETAILS
Precited structure:
Click on the image to enlarge
Download model 1 structure: PDB, PyMOL session
List of hydrogen bonds:
| Donor | Acceptor | Distance |
|---|---|---|
| B, 344, GLY, HA1 | A, 341, VAL, O | 3.42Å |
| A, 344, GLY, HA1 | B, 341, VAL, O | 3.42Å |