Killer cell immunoglobulin-like receptor 3DL1

UniProt data

UniProt name: KI3L1_HUMAN (P43629)

Gene name: KIR3DL1; Synonyms=CD158E, NKAT3, NKB1

Organism: Homo sapiens (Human).

Function: Receptor on natural killer (NK) cells for HLA Bw4 allele. Inhibits the activity of NK cells thus preventing cell lysis. {ECO:0000269|PubMed:22020283}.

Subcellular location: Cell membrane; Single-pass type I membrane protein.

Transmembrane domains:

  1. 341-360, 20 AA, Helical. {ECO:0000255}.

Sequence: 444 AA

10 20 30 40 50 60 MSLMVVSMAC VGLFLVQRAG PHMGGQDKPF LSAWPSAVVP RGGHVTLRCH YRHRFNNFML 70 80 90 100 110 120 YKEDRIHIPI FHGRIFQESF NMSPVTTAHA GNYTCRGSHP HSPTGWSAPS NPVVIMVTGN 130 140 150 160 170 180 HRKPSLLAHP GPLVKSGERV ILQCWSDIMF EHFFLHKEGI SKDPSRLVGQ IHDGVSKANF 190 200 210 220 230 240 SIGPMMLALA GTYRCYGSVT HTPYQLSAPS DPLDIVVTGP YEKPSLSAQP GPKVQAGESV 250 260 270 280 290 300 TLSCSSRSSY DMYHLSREGG AHERRLPAVR KVNRTFQADF PLGPATHGGT YRCFGSFRHS 310 320 330 340 350 360 PYEWSDPSDP LLVSVTGNPS SSWPSPTEPS SKSGNPRHLH ILIGTSVVII LFILLLFFLL 370 380 390 400 410 420 HLWCSNKKNA AVMDQEPAGN RTANSEDSDE QDPEEVTYAQ LDHCVFTQRK ITRPSQRPKT 430 440 PPTDTILYTE LPNAKPRSKV VSCP

CATM prediction

The sequence of KI3L1_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
    340       350       360 
  |    +    |    +    |   		 (Å) (°) (Å) (°)  
Model 1 HLHILIGTSVVIILFILLLFFLLHLW 7.4 -51.0° 3.3 48.0 -8.7

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 344, GLY, HA1 A, 341, ILE, O 3.42Å
A, 344, GLY, HA1 B, 341, ILE, O 3.42Å