Tumor necrosis factor receptor superfamily member 4

UniProt data

UniProt name: TNR4_HUMAN (P43489)

Gene name: TNFRSF4; Synonyms=TXGP1L

Organism: Homo sapiens (Human).

Function: (Microbial infection) Acts as a receptor for human herpesvirus 6B/HHV-6B. {ECO:0000269|PubMed:23674671}.

Subcellular location: Membrane; Single-pass type I membrane protein.

Transmembrane domains:

  1. 215-235, 21 AA, Helical. {ECO:0000255}.

Sequence: 277 AA

10 20 30 40 50 60 MCVGARRLGR GPCAALLLLG LGLSTVTGLH CVGDTYPSND RCCHECRPGN GMVSRCSRSQ 70 80 90 100 110 120 NTVCRPCGPG FYNDVVSSKP CKPCTWCNLR SGSERKQLCT ATQDTVCRCR AGTQPLDSYK 130 140 150 160 170 180 PGVDCAPCPP GHFSPGDNQA CKPWTNCTLA GKHTLQPASN SSDAICEDRD PPATQPQETQ 190 200 210 220 230 240 GPPARPITVQ PTEAWPRTSQ GPSTRPVEVP GGRAVAAILG LGLVLGLLGP LAILLALYLL 250 260 270 RRDQRLPPDA HKPPGGGSFR TPIQEEQADA HSTLAKI

CATM prediction

The sequence of TNR4_HUMAN returned 6 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
          220       230      
   +    |    +    |    +   		 (Å) (°) (Å) (°)  
Model 1 GRAVAAILGLGLVLGLLGALAILLALY 6.6 -44.8° 0.2 44.9 -37.2
Model 2 GRAVAAILGLGLVLGLLGALAILLALY 6.5 +54.1° 3.3 80.0 -30.7
Model 3 GRAVAAILGLGLVLGLLGALAILLALY 7.1 -42.8° -0.0 34.4 -18.8
Model 4 GRAVAAILGLGLVLGLLGALAILLALY 7.1 -55.0° 2.4 48.2 -12.2
Model 5 GRAVAAILGLGLVLGLLGALAILLALY 7.3 -54.1° 3.6 49.1 -10.2
Model 6 GRAVAAILGLGLVLGLLGALAILLALY 7.4 -46.0° 3.6 36.5 -4.2
Prolines* GRAVAAILGLGLVLGLLGPLAILLALY          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 219, LEU, HA A, 218, ILE, O 3.48Å
B, 222, GLY, HA1 A, 219, LEU, O 2.88Å
B, 223, LEU, HA A, 222, GLY, O 2.57Å
B, 226, GLY, HA1 A, 223, LEU, O 3.27Å
A, 219, LEU, HA B, 218, ILE, O 3.48Å
A, 222, GLY, HA1 B, 219, LEU, O 2.88Å
A, 223, LEU, HA B, 222, GLY, O 2.57Å
A, 226, GLY, HA1 B, 223, LEU, O 3.27Å