Cell surface glycoprotein MUC18

UniProt data

UniProt name: MUC18_HUMAN (P43121)

Gene name: MCAM; Synonyms=MUC18

Organism: Homo sapiens (Human).

Function: Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration. {ECO:0000269|PubMed:11036077, ECO:0000269|PubMed:8292890}.

Subcellular location: Membrane; Single-pass type I membrane protein.

Transmembrane domains:

  1. 560-583, 24 AA, Helical. {ECO:0000255}.

Sequence: 646 AA

10 20 30 40 50 60 MGLPRLVCAF LLAACCCCPR VAGVPGEAEQ PAPELVEVEV GSTALLKCGL SQSQGNLSHV 70 80 90 100 110 120 DWFSVHKEKR TLIFRVRQGQ GQSEPGEYEQ RLSLQDRGAT LALTQVTPQD ERIFLCQGKR 130 140 150 160 170 180 PRSQEYRIQL RVYKAPEEPN IQVNPLGIPV NSKEPEEVAT CVGRNGYPIP QVIWYKNGRP 190 200 210 220 230 240 LKEEKNRVHI QSSQTVESSG LYTLQSILKA QLVKEDKDAQ FYCELNYRLP SGNHMKESRE 250 260 270 280 290 300 VTVPVFYPTE KVWLEVEPVG MLKEGDRVEI RCLADGNPPP HFSISKQNPS TREAEEETTN 310 320 330 340 350 360 DNGVLVLEPA RKEHSGRYEC QGLDLDTMIS LLSEPQELLV NYVSDVRVSP AAPERQEGSS 370 380 390 400 410 420 LTLTCEAESS QDLEFQWLRE ETGQVLERGP VLQLHDLKRE AGGGYRCVAS VPSIPGLNRT 430 440 450 460 470 480 QLVNVAIFGP PWMAFKERKV WVKENMVLNL SCEASGHPRP TISWNVNGTA SEQDQDPQRV 490 500 510 520 530 540 LSTLNVLVTP ELLETGVECT ASNDLGKNTS ILFLELVNLT TLTPDSNTTT GLSTSTASPH 550 560 570 580 590 600 TRANSTSTER KLPEPESRGV VIVAVIVCIL VLAVLGAVLY FLYKKGKLPC RRSGKQEITL 610 620 630 640 PPSRKSELVV EVKSDKLPEE MGLLQGSSGD KRAPGDQGEK YIDLRH

CATM prediction

The sequence of MUC18_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
     560       570       580    
   |    +    |    +    |    + 		 (Å) (°) (Å) (°)  
Model 1 SRGVVIVAVIVCILVLAVLGAVLYFLYKKG 6.8 -55.1° 1.5 44.6 -23.1

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 573, ALA, HA A, 572, LEU, O 3.40Å
B, 576, GLY, HA1 A, 573, ALA, O 2.83Å
B, 577, ALA, HA A, 576, GLY, O 3.35Å
A, 573, ALA, HA B, 572, LEU, O 3.40Å
A, 576, GLY, HA1 B, 573, ALA, O 2.83Å
A, 577, ALA, HA B, 576, GLY, O 3.35Å