Leukemia inhibitory factor receptor

UniProt data

UniProt name: LIFR_HUMAN (P42702)

Gene name: LIFR

Organism: Homo sapiens (Human).

Function: Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells.

Subcellular location: Isoform 2: Secreted.

Transmembrane domains:

  1. 834-858, 25 AA, Helical. {ECO:0000255}.

Sequence: 1097 AA

10 20 30 40 50 60 MMDIYVCLKR PSWMVDNKRM RTASNFQWLL STFILLYLMN QVNSQKKGAP HDLKCVTNNL 70 80 90 100 110 120 QVWNCSWKAP SGTGRGTDYE VCIENRSRSC YQLEKTSIKI PALSHGDYEI TINSLHDFGS 130 140 150 160 170 180 STSKFTLNEQ NVSLIPDTPE ILNLSADFST STLYLKWNDR GSVFPHRSNV IWEIKVLRKE 190 200 210 220 230 240 SMELVKLVTH NTTLNGKDTL HHWSWASDMP LECAIHFVEI RCYIDNLHFS GLEEWSDWSP 250 260 270 280 290 300 VKNISWIPDS QTKVFPQDKV ILVGSDITFC CVSQEKVLSA LIGHTNCPLI HLDGENVAIK 310 320 330 340 350 360 IRNISVSASS GTNVVFTTED NIFGTVIFAG YPPDTPQQLN CETHDLKEII CSWNPGRVTA 370 380 390 400 410 420 LVGPRATSYT LVESFSGKYV RLKRAEAPTN ESYQLLFQML PNQEIYNFTL NAHNPLGRSQ 430 440 450 460 470 480 STILVNITEK VYPHTPTSFK VKDINSTAVK LSWHLPGNFA KINFLCEIEI KKSNSVQEQR 490 500 510 520 530 540 NVTIKGVENS SYLVALDKLN PYTLYTFRIR CSTETFWKWS KWSNKKQHLT TEASPSKGPD 550 560 570 580 590 600 TWREWSSDGK NLIIYWKPLP INEANGKILS YNVSCSSDEE TQSLSEIPDP QHKAEIRLDK 610 620 630 640 650 660 NDYIISVVAK NSVGSSPPSK IASMEIPNDD LKIEQVVGMG KGILLTWHYD PNMTCDYVIK 670 680 690 700 710 720 WCNSSRSEPC LMDWRKVPSN STETVIESDE FRPGIRYNFF LYGCRNQGYQ LLRSMIGYIE 730 740 750 760 770 780 ELAPIVAPNF TVEDTSADSI LVKWEDIPVE ELRGFLRGYL FYFGKGERDT SKMRVLESGR 790 800 810 820 830 840 SDIKVKNITD ISQKTLRIAD LQGKTSYHLV LRAYTDGGVG PEKSMYVVTK ENSVGLIIAI 850 860 870 880 890 900 LIPVAVAVIV GVVTSILCYR KREWIKETFY PDIPNPENCK ALQFQKSVCE GSSALKTLEM 910 920 930 940 950 960 NPCTPNNVEV LETRSAFPKI EDTEIISPVA ERPEDRSDAE PENHVVVSYC PPIIEEEIPN 970 980 990 1000 1010 1020 PAADEAGGTA QVIYIDVQSM YQPQAKPEEE QENDPVGGAG YKPQMHLPIN STVEDIAAEE 1030 1040 1050 1060 1070 1080 DLDKTAGYRP QANVNTWNLV SPDSPRSIDS NSEIVSFGSP CSINSRQFLI PPKDEDSPKS 1090 NGGGWSFTNF FQNKPND

CATM prediction

The sequence of LIFR_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
           840       850       86
    +    |    +    |    +    | 		 (Å) (°) (Å) (°)  
Model 1 ENSVGLIIAILIAVAVAVIVGVVTSILCYRK 7.2 -51.0° 3.3 48.0 -14.3
Model 2 ENSVGLIIAILIAVAVAVIVGVVTSILCYRK 7.4 -43.0° 3.5 50.0 -3.4
Prolines* ENSVGLIIAILIPVAVAVIVGVVTSILCYRK          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 848, VAL, HA A, 847, ALA, O 3.12Å
B, 851, GLY, HA1 A, 848, VAL, O 3.18Å
A, 848, VAL, HA B, 847, ALA, O 3.12Å
A, 851, GLY, HA1 B, 848, VAL, O 3.18Å