Interleukin-12 receptor subunit beta-1

UniProt data

UniProt name: I12R1_HUMAN (P42701)

Gene name: IL12RB1; Synonyms=IL12R, IL12RB

Organism: Homo sapiens (Human).

Function: Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade. {ECO:0000269|PubMed:12023369}.

Subcellular location: Membrane; Single-pass type I membrane protein.

Transmembrane domains:

  1. 546-570, 25 AA, Helical. {ECO:0000255}.

Sequence: 662 AA

10 20 30 40 50 60 MEPLVTWVVP LLFLFLLSRQ GAACRTSECC FQDPPYPDAD SGSASGPRDL RCYRISSDRY 70 80 90 100 110 120 ECSWQYEGPT AGVSHFLRCC LSSGRCCYFA AGSATRLQFS DQAGVSVLYT VTLWVESWAR 130 140 150 160 170 180 NQTEKSPEVT LQLYNSVKYE PPLGDIKVSK LAGQLRMEWE TPDNQVGAEV QFRHRTPSSP 190 200 210 220 230 240 WKLGDCGPQD DDTESCLCPL EMNVAQEFQL RRRQLGSQGS SWSKWSSPVC VPPENPPQPQ 250 260 270 280 290 300 VRFSVEQLGQ DGRRRLTLKE QPTQLELPEG CQGLAPGTEV TYRLQLHMLS CPCKAKATRT 310 320 330 340 350 360 LHLGKMPYLS GAAYNVAVIS SNQFGPGLNQ TWHIPADTHT EPVALNISVG TNGTTMYWPA 370 380 390 400 410 420 RAQSMTYCIE WQPVGQDGGL ATCSLTAPQD PDPAGMATYS WSRESGAMGQ EKCYYITIFA 430 440 450 460 470 480 SAHPEKLTLW STVLSTYHFG GNASAAGTPH HVSVKNHSLD SVSVDWAPSL LSTCPGVLKE 490 500 510 520 530 540 YVVRCRDEDS KQVSEHPVQP TETQVTLSGL RAGVAYTVQV RADTAWLRGV WSQPQRFSIE 550 560 570 580 590 600 VQVSDWLIFF ASLGSFLSIL LVGVLGYLGL NRAARHLCPP LPTPCASSAI EFPGGKETWQ 610 620 630 640 650 660 WINPVDFQEE ASLQEALVVE MSWDKGERTE PLEKTELPEG APELALDTEL SLEDGDRCKA KM

CATM prediction

The sequence of I12R1_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
         550       560       570 
  +    |    +    |    +    |   		 (Å) (°) (Å) (°)  
Model 1 VSDWLIFFASLGSFLSILLVGVLGYLGLNRA 7.0 -48.8° 2.8 32.0 -0.0

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 551, ALA, HA A, 550, PHE, O 3.31Å
B, 554, GLY, HA1 A, 551, ALA, O 3.07Å
B, 555, SER, HA A, 558, SER, OG 2.78Å
A, 551, ALA, HA B, 550, PHE, O 3.31Å
A, 554, GLY, HA1 B, 551, ALA, O 3.07Å
A, 555, SER, HA B, 558, SER, OG 3.19Å