T-cell surface protein tactile

UniProt data

UniProt name: TACT_HUMAN (P40200)

Gene name: CD96

Organism: Homo sapiens (Human).

Function: May be involved in adhesive interactions of activated T and NK cells during the late phase of the immune response. Promotes NK cell-target adhesion by interacting with PVR present on target cells. May function at a time after T and NK cells have penetrated the endothelium using integrins and selectins, when they are actively engaging diseased cells and moving within areas of inflammation.

Subcellular location: Membrane; Single-pass type I membrane protein.

Transmembrane domains:

  1. 520-540, 21 AA, Helical. {ECO:0000255}.

Sequence: 585 AA

10 20 30 40 50 60 MEKKWKYCAV YYIIQIHFVK GVWEKTVNTE ENVYATLGSD VNLTCQTQTV GFFVQMQWSK 70 80 90 100 110 120 VTNKIDLIAV YHPQYGFYCA YGRPCESLVT FTETPENGSK WTLHLRNMSC SVSGRYECML 130 140 150 160 170 180 VLYPEGIQTK IYNLLIQTHV TADEWNSNHT IEIEINQTLE IPCFQNSSSK ISSEFTYAWS 190 200 210 220 230 240 VENSSTDSWV LLSKGIKEDN GTQETLISQN HLISNSTLLK DRVKLGTDYR LHLSPVQIFD 250 260 270 280 290 300 DGRKFSCHIR VGPNKILRSS TTVKVFAKPE IPVIVENNST DVLVERRFTC LLKNVFPKAN 310 320 330 340 350 360 ITWFIDGSFL HDEKEGIYIT NEERKGKDGF LELKSVLTRV HSNKPAQSDN LTIWCMALSP 370 380 390 400 410 420 VPGNKVWNIS SEKITFLLGS EISSTDPPLS VTESTLDTQP SPASSVSPAR YPATSSVTLV 430 440 450 460 470 480 DVSALRPNTT PQPSNSSMTT RGFNYPWTSS GTDTKKSVSR IPSETYSSSP SGAGSTLHDN 490 500 510 520 530 540 VFTSTARAFS EVPTTANGST KTNHVHITGI VVNKPKDGMS WPVIVAALLF CCMILFGLGV 550 560 570 580 RKWCQYQKEI MERPPPFKPP PPPIKYTCIQ EPNESDLPYH EMETL

CATM prediction

The sequence of TACT_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
     520       530       540 
   |    +    |    +    |   		 (Å) (°) (Å) (°)  
Model 1 DGMSWAVIVAALLFCCMILFGLGVRKW 7.0 -50.0° 2.8 47.3 -19.7
Prolines* DGMSWPVIVAALLFCCMILFGLGVRKW          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 534, ILE, HA A, 533, MET, O 3.01Å
B, 537, GLY, HA1 A, 534, ILE, O 2.96Å
A, 534, ILE, HA B, 533, MET, O 3.01Å
A, 537, GLY, HA1 B, 534, ILE, O 2.96Å