Carcinoembryonic antigen-related cell adhesion molecule 3

UniProt data

UniProt name: CEAM3_HUMAN (P40198)

Gene name: CEACAM3; Synonyms=CD66D, CGM1

Organism: Homo sapiens (Human).

Function: Major granulocyte receptor mediating recognition and efficient opsonin-independent phagocytosis of CEACAM-binding microorganisms, including Neissiria, Moxarella and Haemophilus species, thus playing an important role in the clearance of pathogens by the innate immune system. Responsible for RAC1 stimulation in the course of pathogen phagocytosis. {ECO:0000269|PubMed:12864848, ECO:0000269|PubMed:14707113}.

Subcellular location: Membrane; Single-pass type I membrane protein.

Transmembrane domains:

  1. 156-176, 21 AA, Helical. {ECO:0000255}.

Sequence: 252 AA

10 20 30 40 50 60 MGPPSASPHR ECIPWQGLLL TASLLNFWNP PTTAKLTIES MPLSVAEGKE VLLLVHNLPQ 70 80 90 100 110 120 HLFGYSWYKG ERVDGNSLIV GYVIGTQQAT PGAAYSGRET IYTNASLLIQ NVTQNDIGFY 130 140 150 160 170 180 TLQVIKSDLV NEEATGQFHV YQENAPGLPV GAVAGIVTGV LVGVALVAAL VCFLLLAKTG 190 200 210 220 230 240 RTSIQRDLKE QQPQALAPGR GPSHSSAFSM SPLSTAQAPL PNPRTAASIY EELLKHDTNI 250 YCRMDHKAEV AS

CATM prediction

The sequence of CEAM3_HUMAN returned 4 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
         160       170       
  +    |    +    |    +    		 (Å) (°) (Å) (°)  
Model 1 VAGIVTGVLVGVALVAALVCFLLLAKT 6.6 -48.1° 0.7 54.2 -32.7
Model 2 VAGIVTGVLVGVALVAALVCFLLLAKT 6.8 -25.0° 5.5 50.0 -28.5
Model 3 VAGIVTGVLVGVALVAALVCFLLLAKT 6.4 -38.0° 6.0 59.0 -20.9
Model 4 VAGIVTGVLVGVALVAALVCFLLLAKT 6.5 -55.0° 3.6 63.0 -18.2

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 159, GLY, HA1 A, 156, ILE, O 2.77Å
B, 160, VAL, HA A, 159, GLY, O 2.76Å
A, 159, GLY, HA1 B, 156, ILE, O 2.77Å
A, 160, VAL, HA B, 159, GLY, O 2.76Å