Integrin alpha-E

UniProt data

UniProt name: ITAE_HUMAN (P38570)

Gene name: ITGAE

Organism: Homo sapiens (Human).

Function: Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers.

Subcellular location: Membrane; Single-pass type I membrane protein.

Transmembrane domains:

  1. 1125-1147, 23 AA, Helical. {ECO:0000255}.

Sequence: 1179 AA

10 20 30 40 50 60 MWLFHTLLCI ASLALLAAFN VDVARPWLTP KGGAPFVLSS LLHQDPSTNQ TWLLVTSPRT 70 80 90 100 110 120 KRTPGPLHRC SLVQDEILCH PVEHVPIPKG RHRGVTVVRS HHGVLICIQV LVRRPHSLSS 130 140 150 160 170 180 ELTGTCSLLG PDLRPQAQAN FFDLENLLDP DARVDTGDCY SNKEGGGEDD VNTARQRRAL 190 200 210 220 230 240 EKEEEEDKEE EEDEEEEEAG TEIAIILDGS GSIDPPDFQR AKDFISNMMR NFYEKCFECN 250 260 270 280 290 300 FALVQYGGVI QTEFDLRDSQ DVMASLARVQ NITQVGSVTK TASAMQHVLD SIFTSSHGSR 310 320 330 340 350 360 RKASKVMVVL TDGGIFEDPL NLTTVINSPK MQGVERFAIG VGEEFKSART ARELNLIASD 370 380 390 400 410 420 PDETHAFKVT NYMALDGLLS KLRYNIISME GTVGDALHYQ LAQIGFSAQI LDERQVLLGA 430 440 450 460 470 480 VGAFDWSGGA LLYDTRSRRG RFLNQTAAAA ADAEAAQYSY LGYAVAVLHK TCSLSYIAGA 490 500 510 520 530 540 PRYKHHGAVF ELQKEGREAS FLPVLEGEQM GSYFGSELCP VDIDMDGSTD FLLVAAPFYH 550 560 570 580 590 600 VHGEEGRVYV YRLSEQDGSF SLARILSGHP GFTNARFGFA MAAMGDLSQD KLTDVAIGAP 610 620 630 640 650 660 LEGFGADDGA SFGSVYIYNG HWDGLSASPS QRIRASTVAP GLQYFGMSMA GGFDISGDGL 670 680 690 700 710 720 ADITVGTLGQ AVVFRSRPVV RLKVSMAFTP SALPIGFNGV VNVRLCFEIS SVTTASESGL 730 740 750 760 770 780 REALLNFTLD VDVGKQRRRL QCSDVRSCLG CLREWSSGSQ LCEDLLLMPT EGELCEEDCF 790 800 810 820 830 840 SNASVKVSYQ LQTPEGQTDH PQPILDRYTE PFAIFQLPYE KACKNKLFCV AELQLATTVS 850 860 870 880 890 900 QQELVVGLTK ELTLNINLTN SGEDSYMTSM ALNYPRNLQL KRMQKPPSPN IQCDDPQPVA 910 920 930 940 950 960 SVLIMNCRIG HPVLKRSSAH VSVVWQLEEN AFPNRTADIT VTVTNSNERR SLANETHTLQ 970 980 990 1000 1010 1020 FRHGFVAVLS KPSIMYVNTG QGLSHHKEFL FHVHGENLFG AEYQLQICVP TKLRGLQVVA 1030 1040 1050 1060 1070 1080 VKKLTRTQAS TVCTWSQERA CAYSSVQHVE EWHSVSCVIA SDKENVTVAA EISWDHSEEL 1090 1100 1110 1120 1130 1140 LKDVTELQIL GEISFNKSLY EGLNAENHRT KITVVFLKDE KYHSLPIIIK GSVGGLLVLI 1150 1160 1170 VILVILFKCG FFKRKYQQLN LESIRKAQLK SENLLEEEN

CATM prediction

The sequence of ITAE_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
          1130      1140      1
   +    |    +    |    +    |		 (Å) (°) (Å) (°)  
Model 1 YHSLAIIIKGSVGGLLVLIVILVILFKCG 6.4 -55.0° 5.8 47.3 -21.3
Model 2 YHSLAIIIKGSVGGLLVLIVILVILFKCG 7.0 -52.0° 1.8 35.0 -10.8
Prolines* YHSLPIIIKGSVGGLLVLIVILVILFKCG          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 1131, GLY, HA1 A, 1128, ILE, O 2.77Å
B, 1132, SER, HA A, 1131, GLY, O 2.53Å
B, 1135, GLY, HA1 A, 1132, SER, O 3.31Å
A, 1131, GLY, HA1 B, 1128, ILE, O 2.77Å
A, 1132, SER, HA B, 1131, GLY, O 2.53Å
A, 1135, GLY, HA1 B, 1132, SER, O 3.31Å