Interferon gamma receptor 2 {ECO:0000312|HGNC:HGNC:5440}

UniProt data

UniProt name: INGR2_HUMAN (P38484)

Gene name: IFNGR2 {ECO:0000312|HGNC:HGNC:5440}

Organism: Homo sapiens (Human).

Function: Associates with IFNGR1 to form a receptor for the cytokine interferon gamma (IFNG) (PubMed:8124716, PubMed:7673114,PubMed:7615558). Ligand binding stimulates activation of the JAK/STAT signaling pathway (PubMed:8124716, PubMed:7673114, PubMed:15356148). Required for signal transduction in contrast to other receptor subunit responsible for ligand binding (PubMed:7673114). {ECO:0000269|PubMed:15356148, ECO:0000269|PubMed:7615558, ECO:0000269|PubMed:7673114, ECO:0000269|PubMed:8124716}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:15356148, ECO:0000269|PubMed:15924140}; Single-pass type I membrane protein {ECO:0000255}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:10605012}; Single-pass type I membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:23963039}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:23963039}; Single-pass type I membrane protein {ECO:0000255}. Cytoplasm {ECO:0000269|PubMed:10605012}. Note=Has low cell surface expression and high cytoplasmic expression in T cells. The bias towards cytoplasmic expression may be due to ligand-independent receptor internalization and recycling. {ECO:0000269|PubMed:10605012, ECO:0000269|PubMed:15356148}.

Transmembrane domains:

  1. 248-268, 21 AA, Helical. {ECO:0000255}.

Sequence: 337 AA

10 20 30 40 50 60 MRPTLLWSLL LLLGVFAAAA AAPPDPLSQL PAPQHPKIRL YNAEQVLSWE PVALSNSTRP 70 80 90 100 110 120 VVYQVQFKYT DSKWFTADIM SIGVNCTQIT ATECDFTAAS PSAGFPMDFN VTLRLRAELG 130 140 150 160 170 180 ALHSAWVTMP WFQHYRNVTV GPPENIEVTP GEGSLIIRFS SPFDIADTST AFFCYYVHYW 190 200 210 220 230 240 EKGGIQQVKG PFRSNSISLD NLKPSRVYCL QVQAQLLWNK SNIFRVGHLS NISCYETMAD 250 260 270 280 290 300 ASTELQQVIL ISVGTFSLLS VLAGACFFLV LKYRGLIKYW FHTPPSIPLQ IEEYLKDPTQ 310 320 330 PILEALDKDS SPKDDVWDSV SIISFPEKEQ EDVLQTL

CATM prediction

The sequence of INGR2_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
       250       260       27
+    |    +    |    +    | 		 (Å) (°) (Å) (°)  
Model 1 LQQVILISVGTFSLLSVLAGACFFLVL 7.0 -50.9° 2.4 44.9 -13.9
Model 2 LQQVILISVGTFSLLSVLAGACFFLVL 7.2 -55.5° 2.4 48.1 -5.6

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 261, VAL, HA A, 260, SER, O 3.19Å
B, 264, GLY, HA1 A, 261, VAL, O 2.97Å
A, 261, VAL, HA B, 260, SER, O 3.19Å
A, 264, GLY, HA1 B, 261, VAL, O 2.97Å