Estradiol 17-beta-dehydrogenase 2

UniProt data

UniProt name: DHB2_HUMAN (P37059)

Gene name: HSD17B2; Synonyms=EDH17B2, SDR9C2

Organism: Homo sapiens (Human).

Function: Capable of catalyzing the interconversion of testosterone and androstenedione, as well as estradiol and estrone. Also has 20-alpha-HSD activity. Uses NADH while EDH17B3 uses NADPH.

Subcellular location: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 4-24, 21 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.

Sequence: 387 AA

10 20 30 40 50 60 MSTFFSDTAW ICLAVPTVLC GTVFCKYKKS SGQLWSWMVC LAGLCAVCLL ILSPFWGLIL 70 80 90 100 110 120 FSVSCFLMYT YLSGQELLPV DQKAVLVTGG DCGLGHALCK YLDELGFTVF AGVLNENGPG 130 140 150 160 170 180 AEELRRTCSP RLSVLQMDIT KPVQIKDAYS KVAAMLQDRG LWAVINNAGV LGFPTDGELL 190 200 210 220 230 240 LMTDYKQCMA VNFFGTVEVT KTFLPLLRKS KGRLVNVSSM GGGAPMERLA SYGSSKAAVT 250 260 270 280 290 300 MFSSVMRLEL SKWGIKVASI QPGGFLTNIA GTSDKWEKLE KDILDHLPAE VQEDYGQDYI 310 320 330 340 350 360 LAQRNFLLLI NSLASKDFSP VLRDIQHAIL AKSPFAYYTP GKGAYLWICL AHYLPIGIYD 370 380 YFAKRHFGQD KPMPRALRMP NYKKKAT

CATM prediction

The sequence of DHB2_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
           10        20      
    +    |    +    |    +  		 (Å) (°) (Å) (°)  
Model 1 MSTFFSDTAWICLAVATVLCGTVFCKY 7.2 -46.8° 1.3 45.0 -14.6
Prolines* MSTFFSDTAWICLAVPTVLCGTVFCKY          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 21, GLY, HA1 A, 18, VAL, O 3.21Å
B, 22, THR, HA A, 21, GLY, O 3.47Å
A, 21, GLY, HA1 B, 18, VAL, O 3.21Å
A, 22, THR, HA B, 21, GLY, O 3.47Å