Serine/threonine-protein kinase receptor R3

UniProt data

UniProt name: ACVL1_HUMAN (P37023)

Gene name: ACVRL1; Synonyms=ACVRLK1, ALK1

Organism: Homo sapiens (Human).

Function: Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well. {ECO:0000269|PubMed:22718755, ECO:0000269|PubMed:22799562, ECO:0000269|PubMed:26176610}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:26176610}; Single-pass type I membrane protein {ECO:0000255}.

Transmembrane domains:

  1. 119-141, 23 AA, Helical. {ECO:0000255}.

Sequence: 503 AA

10 20 30 40 50 60 MTLGSPRKGL LMLLMALVTQ GDPVKPSRGP LVTCTCESPH CKGPTCRGAW CTVVLVREEG 70 80 90 100 110 120 RHPQEHRGCG NLHRELCRGR PTEFVNHYCC DSHLCNHNVS LVLEATQPPS EQPGTDGQLA 130 140 150 160 170 180 LILGPVLALL ALVALGVLGL WHVRRRQEKQ RGLHSELGES SLILKASEQG DSMLGDLLDS 190 200 210 220 230 240 DCTTGSGSGL PFLVQRTVAR QVALVECVGK GRYGEVWRGL WHGESVAVKI FSSRDEQSWF 250 260 270 280 290 300 RETEIYNTVL LRHDNILGFI ASDMTSRNSS TQLWLITHYH EHGSLYDFLQ RQTLEPHLAL 310 320 330 340 350 360 RLAVSAACGL AHLHVEIFGT QGKPAIAHRD FKSRNVLVKS NLQCCIADLG LAVMHSQGSD 370 380 390 400 410 420 YLDIGNNPRV GTKRYMAPEV LDEQIRTDCF ESYKWTDIWA FGLVLWEIAR RTIVNGIVED 430 440 450 460 470 480 YRPPFYDVVP NDPSFEDMKK VVCVDQQTPT IPNRLAADPV LSGLAQMMRE CWYPNPSARL 490 500 TALRIKKTLQ KISNSPEKPK VIQ

CATM prediction

The sequence of ACVL1_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
      120       130       140  
    |    +    |    +    |    		 (Å) (°) (Å) (°)  
Model 1 DGQLALILGAVLALLALVALGVLGLWHVR 7.3 -41.8° 2.8 49.7 -18.7
Model 2 DGQLALILGAVLALLALVALGVLGLWHVR 7.4 -22.0° 3.1 40.0 -0.8
Prolines* DGQLALILGPVLALLALVALGVLGLWHVR          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 121, LEU, HA A, 120, ALA, O 2.91Å
B, 124, GLY, HA1 A, 121, LEU, O 3.11Å
A, 121, LEU, HA B, 120, ALA, O 2.91Å
A, 124, GLY, HA1 B, 121, LEU, O 3.11Å