UDP-glucuronosyltransferase 2B10

UniProt data

UniProt name: UDB10_HUMAN (P36537)

Gene name: UGT2B10

Organism: Homo sapiens (Human).

Function: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.

Subcellular location: Microsome membrane {ECO:0000305}; Single- pass membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 492-512, 21 AA, Helical. {ECO:0000255}.

Sequence: 528 AA

10 20 30 40 50 60 MALKWTTVLL IQLSFYFSSG SCGKVLVWAA EYSLWMNMKT ILKELVQRGH EVTVLASSAS 70 80 90 100 110 120 ILFDPNDSST LKLEVYPTSL TKTEFENIIM QLVKRLSEIQ KDTFWLPFSQ EQEILWAIND 130 140 150 160 170 180 IIRNFCKDVV SNKKLMKKLQ ESRFDIVFAD AYLPCGELLA ELFNIPFVYS HSFSPGYSFE 190 200 210 220 230 240 RHSGGFIFPP SYVPVVMSKL SDQMTFMERV KNMLYVLYFD FWFQIFNMKK WDQFYSEVLG 250 260 270 280 290 300 RPTTLSETMR KADIWLMRNS WNFKFPHPFL PNVDFVGGLH CKPAKPLPKE MEEFVQSSGE 310 320 330 340 350 360 NGVVVFSLGS MVSNMTEERA NVIATALAKI PQKVLWRFDG NKPDALGLNT RLYKWIPQND 370 380 390 400 410 420 LLGHPKTRAF ITHGGANGIY EAIYHGIPMV GIPLFFDQPD NIAHMKAKGA AVRVDFNTMS 430 440 450 460 470 480 STDLLNALKT VINDPSYKEN IMKLSRIQHD QPVKPLDRAV FWIEFVMRHK GAKHLRVAAH 490 500 510 520 NLTWFQYHSL DVIGFLLACV ATVLFIITKC CLFCFWKFAR KGKKGKRD

CATM prediction

The sequence of UDB10_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
   490       500       510   
 |    +    |    +    |    +		 (Å) (°) (Å) (°)  
Model 1 SLDVIGFLLACVATVLFIITKCCLFCF 7.1 -44.0° 1.8 45.0 -7.7

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 495, PHE, HA A, 494, GLY, O 3.33Å
A, 495, PHE, HA B, 494, GLY, O 3.33Å