Gamma-glutamyltransferase 5

UniProt data

UniProt name: GGT5_HUMAN (P36269)

Gene name: GGT5; Synonyms=GGTLA1

Organism: Homo sapiens (Human).

Function: Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4).

Subcellular location: Membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.

Transmembrane domains:

  1. 9-29, 21 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.

Sequence: 586 AA

10 20 30 40 50 60 MARGYGATVS LVLLGLGLAL AVIVLAVVLS RHQAPCGPQA FAHAAVAADS KVCSDIGRAI 70 80 90 100 110 120 LQQQGSPVDA TIAALVCTSV VNPQSMGLGG GVIFTIYNVT TGKVEVINAR ETVPASHAPS 130 140 150 160 170 180 LLDQCAQALP LGTGAQWIGV PGELRGYAEA HRRHGRLPWA QLFQPTIALL RGGHVVAPVL 190 200 210 220 230 240 SRFLHNSILR PSLQASTLRQ LFFNGTEPLR PQDPLPWPAL ATTLETVATE GVEVFYTGRL 250 260 270 280 290 300 GQMLVEDIAK EGSQLTLQDL AKFQPEVVDA LEVPLGDYTL YSPPPPAGGA ILSFILNVLR 310 320 330 340 350 360 GFNFSTESMA RPEGRVNVYH HLVETLKFAK GQRWRLGDPR SHPKLQNASR DLLGETLAQL 370 380 390 400 410 420 IRQQIDGRGD HQLSHYSLAE AWGHGTGTSH VSVLGEDGSA VAATSTINTP FGAMVYSPRT 430 440 450 460 470 480 GIILNNELLD LCERCPRGSG TTPSPVSGDR VGGAPGRCWP PVPGERSPSS MVPSILINKA 490 500 510 520 530 540 QGSKLVIGGA GGELIISAVA QAIMSKLWLG FDLRAAIAAP ILHVNSKGCV EYEPNFSQEV 550 560 570 580 QRGLQDRGQN QTQRPFFLNV VQAVSQEGAC VYAVSDLRKS GEAAGY

CATM prediction

The sequence of GGT5_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
      10        20        30 
    |    +    |    +    |  		 (Å) (°) (Å) (°)  
Model 1 GATVSLVLLGLGLALAVIVLAVVLSRH 7.3 -48.0° 0.7 54.1 -1.1

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 15, GLY, HA1 A, 12, VAL, O 3.39Å
B, 16, LEU, HA A, 15, GLY, O 3.49Å
A, 15, GLY, HA1 B, 12, VAL, O 3.39Å
A, 16, LEU, HA B, 15, GLY, O 3.49Å