Basigin

UniProt data

UniProt name: BASI_HUMAN (P35613)

Gene name: BSG; ORFNames=UNQ6505/PRO21383

Organism: Homo sapiens (Human).

Function: Plays an important role in targeting the monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to the plasma membrane. Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). Seems to be a receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic processes. {ECO:0000269|PubMed:17127621}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:15946952, ECO:0000269|PubMed:17127621, ECO:0000269|PubMed:21536654}; Single- pass type I membrane protein {ECO:0000303|PubMed:15946952}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. In spermatozoa, localized on the principal piece of caput and in the middle piece during transit in the corpus and cauda epididymides (By similarity). {ECO:0000250|UniProtKB:P18572, ECO:0000269|PubMed:17081065}.

Transmembrane domains:

  1. 324-344, 21 AA, Helical. {ECO:0000255}.

Sequence: 385 AA

10 20 30 40 50 60 MAAALFVLLG FALLGTHGAS GAAGFVQAPL SQQRWVGGSV ELHCEAVGSP VPEIQWWFEG 70 80 90 100 110 120 QGPNDTCSQL WDGARLDRVH IHATYHQHAA STISIDTLVE EDTGTYECRA SNDPDRNHLT 130 140 150 160 170 180 RAPRVKWVRA QAVVLVLEPG TVFTTVEDLG SKILLTCSLN DSATEVTGHR WLKGGVVLKE 190 200 210 220 230 240 DALPGQKTEF KVDSDDQWGE YSCVFLPEPM GTANIQLHGP PRVKAVKSSE HINEGETAML 250 260 270 280 290 300 VCKSESVPPV TDWAWYKITD SEDKALMNGS ESRFFVSSSQ GRSELHIENL NMEADPGQYR 310 320 330 340 350 360 CNGTSSKGSD QAIITLRVRS HLAALWPFLG IVAEVLVLVT IIFIYEKRRK PEDVLDDDDA 370 380 GSAPLKSSGQ HQNDKGKNVR QRNSS

CATM prediction

The sequence of BASI_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
           330       340     
    +    |    +    |    +  		 (Å) (°) (Å) (°)  
Model 1 HLAALWAFLGIVAEVLVLVTIIFIYEK 7.0 -50.7° 2.4 44.7 -19.2
Prolines* HLAALWPFLGIVAEVLVLVTIIFIYEK          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 327, ALA, HA A, 326, TRP, O 3.11Å
B, 330, GLY, HA1 A, 327, ALA, O 2.92Å
A, 327, ALA, HA B, 326, TRP, O 3.11Å
A, 330, GLY, HA1 B, 327, ALA, O 2.92Å