Tyrosine-protein kinase receptor Tie-1

UniProt data

UniProt name: TIE1_HUMAN (P35590)

Gene name: TIE1; Synonyms=TIE

Organism: Homo sapiens (Human).

Function: Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis. {ECO:0000269|PubMed:20227369}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:15851516, ECO:0000269|PubMed:20227369}; Single-pass type I membrane protein {ECO:0000269|PubMed:15851516, ECO:0000269|PubMed:20227369}.

Transmembrane domains:

  1. 760-784, 25 AA, Helical. {ECO:0000255}.

Sequence: 1138 AA

10 20 30 40 50 60 MVWRVPPFLL PILFLASHVG AAVDLTLLAN LRLTDPQRFF LTCVSGEAGA GRGSDAWGPP 70 80 90 100 110 120 LLLEKDDRIV RTPPGPPLRL ARNGSHQVTL RGFSKPSDLV GVFSCVGGAG ARRTRVIYVH 130 140 150 160 170 180 NSPGAHLLPD KVTHTVNKGD TAVLSARVHK EKQTDVIWKS NGSYFYTLDW HEAQDGRFLL 190 200 210 220 230 240 QLPNVQPPSS GIYSATYLEA SPLGSAFFRL IVRGCGAGRW GPGCTKECPG CLHGGVCHDH 250 260 270 280 290 300 DGECVCPPGF TGTRCEQACR EGRFGQSCQE QCPGISGCRG LTFCLPDPYG CSCGSGWRGS 310 320 330 340 350 360 QCQEACAPGH FGADCRLQCQ CQNGGTCDRF SGCVCPSGWH GVHCEKSDRI PQILNMASEL 370 380 390 400 410 420 EFNLETMPRI NCAAAGNPFP VRGSIELRKP DGTVLLSTKA IVEPEKTTAE FEVPRLVLAD 430 440 450 460 470 480 SGFWECRVST SGGQDSRRFK VNVKVPPVPL AAPRLLTKQS RQLVVSPLVS FSGDGPISTV 490 500 510 520 530 540 RLHYRPQDST MDWSTIVVDP SENVTLMNLR PKTGYSVRVQ LSRPGEGGEG AWGPPTLMTT 550 560 570 580 590 600 DCPEPLLQPW LEGWHVEGTD RLRVSWSLPL VPGPLVGDGF LLRLWDGTRG QERRENVSSP 610 620 630 640 650 660 QARTALLTGL TPGTHYQLDV QLYHCTLLGP ASPPAHVLLP PSGPPAPRHL HAQALSDSEI 670 680 690 700 710 720 QLTWKHPEAL PGPISKYVVE VQVAGGAGDP LWIDVDRPEE TSTIIRGLNA STRYLFRMRA 730 740 750 760 770 780 SIQGLGDWSN TVEESTLGNG LQAEGPVQES RAAEEGLDQQ LILAVVGSVS ATCLTILAAL 790 800 810 820 830 840 LTLVCIRRSC LHRRRTFTYQ SGSGEETILQ FSSGTLTLTR RPKLQPEPLS YPVLEWEDIT 850 860 870 880 890 900 FEDLIGEGNF GQVIRAMIKK DGLKMNAAIK MLKEYASEND HRDFAGELEV LCKLGHHPNI 910 920 930 940 950 960 INLLGACKNR GYLYIAIEYA PYGNLLDFLR KSRVLETDPA FAREHGTAST LSSRQLLRFA 970 980 990 1000 1010 1020 SDAANGMQYL SEKQFIHRDL AARNVLVGEN LASKIADFGL SRGEEVYVKK TMGRLPVRWM 1030 1040 1050 1060 1070 1080 AIESLNYSVY TTKSDVWSFG VLLWEIVSLG GTPYCGMTCA ELYEKLPQGY RMEQPRNCDD 1090 1100 1110 1120 1130 EVYELMRQCW RDRPYERPPF AQIALQLGRM LEARKAYVNM SLFENFTYAG IDATAEEA

CATM prediction

The sequence of TIE1_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
     760       770       780     
   |    +    |    +    |    +  		 (Å) (°) (Å) (°)  
Model 1 LDQQLILAVVGSVSATCLTILAALLTLVCIR 7.0 -53.0° 2.0 44.8 -24.1
Model 2 LDQQLILAVVGSVSATCLTILAALLTLVCIR 7.1 -42.8° 0.0 33.8 -4.8

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 764, ALA, HA A, 763, LEU, O 3.31Å
B, 767, GLY, HA1 A, 764, ALA, O 2.84Å
B, 768, SER, HA A, 767, GLY, O 3.36Å
A, 764, ALA, HA B, 763, LEU, O 3.31Å
A, 767, GLY, HA1 B, 764, ALA, O 2.84Å
A, 768, SER, HA B, 767, GLY, O 3.36Å