Tyrosine-protein kinase RYK

UniProt data

UniProt name: RYK_HUMAN (P34925)

Gene name: RYK; Synonyms=JTK5A

Organism: Homo sapiens (Human).

Function: May be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A. Involved in neuron differentiation, axon guidance, corpus callosum establishment and neurite outgrowth. In response to WNT3 stimulation, receptor C- terminal cleavage occurs in its transmembrane region and allows the C-terminal intracellular product to translocate from the cytoplasm to the nucleus where it plays a crucial role in neuronal development. {ECO:0000269|PubMed:15454084}.

Subcellular location: Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=In cells that have undergone neuronal differentiation, the C-terminal cleaved part is translocated from the cytoplasm to the nucleus. {ECO:0000250}.

Transmembrane domains:

  1. 225-252, 28 AA, Helical. {ECO:0000255}.

Sequence: 604 AA

10 20 30 40 50 60 MRGAARLGRP GRSCLPGPAL RAAAAPALLL ARCAVAAAAG LRAAARPRPP ELQSASAGPS 70 80 90 100 110 120 VSLYLSEDEV RRLIGLDAEL YYVRNDLISH YALSFNLLVP SETNFLHFTW HAKSKVEYKL 130 140 150 160 170 180 GFQVDNVLAM DMPQVNISVQ GEVPRTLSVF RVELSCTGKV DSEVMILMQL NLTVNSSKNF 190 200 210 220 230 240 TVLNFKRRKM CYKKLEEVKT SALDKNTSRT IYDPVHAAPT TSTRVFYISV GVCCAVIFLV 250 260 270 280 290 300 AIILAVLHLH NMKRIELDDS ISASSSSQGL SQPSTQTTQY LRADTPNNAT PITSYPTLRI 310 320 330 340 350 360 EKNDLRSVTL LEAKGKVKDI AISRERITLK DVLQEGTFGR IFHGILIDEK DPNKEKQAFV 370 380 390 400 410 420 KTVKDQASEI QVTMMLTESC KLRGLHHRNL LPITHVCIEE GEKPMVILPY MNWGNLKLFL 430 440 450 460 470 480 RQCKLVEANN PQAISQQDLV HMAIQIACGM SYLARREVIH KDLAARNCVI DDTLQVKITD 490 500 510 520 530 540 NALSRDLFPM DYHCLGDNEN RPVRWMALES LVNNEFSSAS DVWAFGVTLW ELMTLGQTPY 550 560 570 580 590 600 VDIDPFEMAA YLKDGYRIAQ PINCPDELFA VMACCWALDP EERPKFQQLV QCLTEFHAAL GAYV

CATM prediction

The sequence of RYK_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
          230       240       250   
   +    |    +    |    +    |    +		 (Å) (°) (Å) (°)  
Model 1 STRVFYISVGVCCAVIFLVAIILAVLHLHNMKRI 7.2 -50.5° 2.8 47.1 -18.4

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 228, ILE, HA A, 227, TYR, O 3.24Å
B, 231, GLY, HA1 A, 228, ILE, O 3.08Å
A, 228, ILE, HA B, 227, TYR, O 3.24Å
A, 231, GLY, HA1 B, 228, ILE, O 3.08Å