UniProt data
UniProt name: SDC2_HUMAN (P34741)
Gene name: SDC2; Synonyms=HSPG1
Organism: Homo sapiens (Human).
Function: Cell surface proteoglycan that bears heparan sulfate. Regulates dendritic arbor morphogenesis (By similarity). {ECO:0000250}.
Subcellular location: Membrane; Single-pass type I membrane protein.
Transmembrane domains:
- 145-169, 25 AA, Helical. {ECO:0000255}.
Sequence: 201 AA
10 20 30 40 50 60
MRRAWILLTL GLVACVSAES RAELTSDKDM YLDNSSIEEA SGVYPIDDDD YASASGSGAD
70 80 90 100 110 120
EDVESPELTT SRPLPKILLT SAAPKVETTT LNIQNKIPAQ TKSPEETDKE KVHLSDSERK
130 140 150 160 170 180
MDPAEEDTNV YTEKHSDSLF KRTEVLAAVI AGGVIGFLFA IFLILLLVYR MRKKDEGSYD
190 200
LGERKPSSAA YQKAPTKEFY A
CATM prediction
The sequence of SDC2_HUMAN returned 4 potential models
The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.
| # | Sequence and interface | d | θ | Z' | ω' | Score |
|---|---|---|---|---|---|---|
| 150 160 170 + | + | + | |
(Å) | (°) | (Å) | (°) | ||
| Model 1 | RTEVLAAVIAGGVIGFLFAIFLILLLVYRMR | 6.4 | -45.2° | 0.1 | 45.1 | -44.9 |
| Model 2 | RTEVLAAVIAGGVIGFLFAIFLILLLVYRMR | 7.3 | -32.0° | 0.6 | 56.9 | -28.4 |
| Model 3 | RTEVLAAVIAGGVIGFLFAIFLILLLVYRMR | 7.1 | -50.8° | 3.3 | 48.1 | -21.1 |
| Model 4 | RTEVLAAVIAGGVIGFLFAIFLILLLVYRMR | 7.3 | -47.0° | 1.4 | 45.0 | -14.7 |
Click on the model number to visualize its details below.
MODEL 1 DETAILS
Precited structure:
Click on the image to enlarge
Download model 1 structure: PDB, PyMOL session
List of hydrogen bonds:
| Donor | Acceptor | Distance |
|---|---|---|
| B, 149, VAL, HA | A, 148, ALA, O | 3.20Å |
| B, 152, GLY, HA1 | A, 149, VAL, O | 2.59Å |
| B, 153, GLY, HA2 | A, 152, GLY, O | 2.40Å |
| B, 156, GLY, HA1 | A, 153, GLY, O | 3.14Å |
| A, 149, VAL, HA | B, 148, ALA, O | 3.20Å |
| A, 152, GLY, HA1 | B, 149, VAL, O | 2.59Å |
| A, 153, GLY, HA2 | B, 152, GLY, O | 2.40Å |
| A, 156, GLY, HA1 | B, 153, GLY, O | 3.14Å |
