CD70 antigen

UniProt data

UniProt name: CD70_HUMAN (P32970)

Gene name: CD70; Synonyms=CD27L, CD27LG, TNFSF7

Organism: Homo sapiens (Human).

Function: Cytokine that binds to CD27. Plays a role in T-cell activation. Induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells.

Subcellular location: Membrane; Single-pass type II membrane protein.

Transmembrane domains:

  1. 18-38, 21 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.

Sequence: 193 AA

10 20 30 40 50 60 MPEEGSGCSV RRRPYGCVLR AALVPLVAGL VICLVVCIQR FAQAQQQLPL ESLGWDVAEL 70 80 90 100 110 120 QLNHTGPQQD PRLYWQGGPA LGRSFLHGPE LDKGQLRIHR DGIYMVHIQV TLAICSSTTA 130 140 150 160 170 180 SRHHPTTLAV GICSPASRSI SLLRLSFHQG CTIASQRLTP LARGDTLCTN LTGTLLPSRN 190 TDETFFGVQW VRP

CATM prediction

The sequence of CD70_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
       20        30        40
+    |    +    |    +    | 		 (Å) (°) (Å) (°)  
Model 1 YGCVLRAALVALVAGLVICLVVCIQRF 6.9 -39.9° 4.1 37.8 -10.0
Prolines* YGCVLRAALVPLVAGLVICLVVCIQRF          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 26, LEU, HA A, 25, ALA, O 2.85Å
B, 29, GLY, HA1 A, 26, LEU, O 3.01Å
A, 26, LEU, HA B, 25, ALA, O 2.85Å
A, 29, GLY, HA1 B, 26, LEU, O 3.01Å