Desmoglein-3

UniProt data

UniProt name: DSG3_HUMAN (P32926)

Gene name: DSG3; Synonyms=CDHF6

Organism: Homo sapiens (Human).

Function: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.

Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell junction, desmosome {ECO:0000250}.

Transmembrane domains:

  1. 616-640, 25 AA, Helical. {ECO:0000255}.

Sequence: 999 AA

10 20 30 40 50 60 MMGLFPRTTG ALAIFVVVIL VHGELRIETK GQYDEEEMTM QQAKRRQKRE WVKFAKPCRE 70 80 90 100 110 120 GEDNSKRNPI AKITSDYQAT QKITYRISGV GIDQPPFGIF VVDKNTGDIN ITAIVDREET 130 140 150 160 170 180 PSFLITCRAL NAQGLDVEKP LILTVKILDI NDNPPVFSQQ IFMGEIEENS ASNSLVMILN 190 200 210 220 230 240 ATDADEPNHL NSKIAFKIVS QEPAGTPMFL LSRNTGEVRT LTNSLDREQA SSYRLVVSGA 250 260 270 280 290 300 DKDGEGLSTQ CECNIKVKDV NDNFPMFRDS QYSARIEENI LSSELLRFQV TDLDEEYTDN 310 320 330 340 350 360 WLAVYFFTSG NEGNWFEIQT DPRTNEGILK VVKALDYEQL QSVKLSIAVK NKAEFHQSVI 370 380 390 400 410 420 SRYRVQSTPV TIQVINVREG IAFRPASKTF TVQKGISSKK LVDYILGTYQ AIDEDTNKAA 430 440 450 460 470 480 SNVKYVMGRN DGGYLMIDSK TAEIKFVKNM NRDSTFIVNK TITAEVLAID EYTGKTSTGT 490 500 510 520 530 540 VYVRVPDFND NCPTAVLEKD AVCSSSPSVV VSARTLNNRY TGPYTFALED QPVKLPAVWS 550 560 570 580 590 600 ITTLNATSAL LRAQEQIPPG VYHISLVLTD SQNNRCEMPR SLTLEVCQCD NRGICGTSYP 610 620 630 640 650 660 TTSPGTRYGR PHSGRLGPAA IGLLLLGLLL LLLAPLLLLT CDCGAGSTGG VTGGFIPVPD 670 680 690 700 710 720 GSEGTIHQWG IEGAHPEDKE ITNICVPPVT ANGADFMESS EVCTNTYARG TAVEGTSGME 730 740 750 760 770 780 MTTKLGAATE SGGAAGFATG TVSGAASGFG AATGVGICSS GQSGTMRTRH STGGTNKDYA 790 800 810 820 830 840 DGAISMNFLD SYFSQKAFAC AEEDDGQEAN DCLLIYDNEG ADATGSPVGS VGCCSFIADD 850 860 870 880 890 900 LDDSFLDSLG PKFKKLAEIS LGVDGEGKEV QPPSKDSGYG IESCGHPIEV QQTGFVKCQT 910 920 930 940 950 960 LSGSQGASAL STSGSVQPAV SIPDPLQHGN YLVTETYSAS GSLVQPSTAG FDPLLTQNVI 970 980 990 VTERVICPIS SVPGNLAGPT QLRGSHTMLC TEDPCSRLI

CATM prediction

The sequence of DSG3_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
         620       630       640 
  +    |    +    |    +    |   		 (Å) (°) (Å) (°)  
Model 1 SGRLGAAAIGLLLLGLLLLLLAALLLLTCDC 7.1 -54.0° 4.8 41.0 -3.8
Model 2 SGRLGAAAIGLLLLGLLLLLLAALLLLTCDC 6.9 -46.0° 4.7 38.0 -2.1
Prolines* SGRLGPAAIGLLLLGLLLLLLAPLLLLTCDC          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 619, ALA, HA A, 618, ALA, O 3.08Å
B, 622, GLY, HA1 A, 619, ALA, O 3.50Å
A, 619, ALA, HA B, 618, ALA, O 3.08Å
A, 622, GLY, HA1 B, 619, ALA, O 3.50Å