UniProt data
UniProt name: STX2_HUMAN (P32856)
Gene name: STX2; Synonyms=EPIM, STX2A, STX2B, STX2C
Organism: Homo sapiens (Human).
Function: Essential for epithelial morphogenesis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm.
Subcellular location: Membrane; Single-pass type IV membrane protein.
Transmembrane domains:
- 265-288, 24 AA, Helical; Anchor for type IV membrane protein. {ECO:0000255}.
Sequence: 288 AA
10 20 30 40 50 60
MRDRLPDLTA CRKNDDGDTV VVVEKDHFMD DFFHQVEEIR NSIDKITQYV EEVKKNHSII
70 80 90 100 110 120
LSAPNPEGKI KEELEDLNKE IKKTANKIRA KLKAIEQSFD QDESGNRTSV DLRIRRTQHS
130 140 150 160 170 180
VLSRKFVEAM AEYNEAQTLF RERSKGRIQR QLEITGRTTT DDELEEMLES GKPSIFTSDI
190 200 210 220 230 240
ISDSQITRQA LNEIESRHKD IMKLETSIRE LHEMFMDMAM FVETQGEMIN NIERNVMNAT
250 260 270 280
DYVEHAKEET KKAIKYQSKA RRKKWIIIAV SVVLVAIIAL IIGLSVGK
CATM prediction
The sequence of STX2_HUMAN returned 1 potential models
The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.
| # | Sequence and interface | d | θ | Z' | ω' | Score |
|---|---|---|---|---|---|---|
| 270 280 + | + | + |
(Å) | (°) | (Å) | (°) | ||
| Model 1 | RKKWIIIAVSVVLVAIIALIIGLSVGK | 7.0 | -37.1° | -0.0 | 36.8 | -9.4 |
Click on the model number to visualize its details below.
MODEL 1 DETAILS
Precited structure:
Click on the image to enlarge
Download model 1 structure: PDB, PyMOL session
List of hydrogen bonds:
| Donor | Acceptor | Distance |
|---|---|---|
| B, 280, LEU, HA | A, 279, ALA, O | 3.03Å |
| B, 283, GLY, HA1 | A, 280, LEU, O | 3.48Å |
| A, 280, LEU, HA | B, 279, ALA, O | 3.03Å |
| A, 283, GLY, HA1 | B, 280, LEU, O | 3.48Å |