Neural cell adhesion molecule L1

UniProt data

UniProt name: L1CAM_HUMAN (P32004)

Gene name: L1CAM; Synonyms=CAML1, MIC5

Organism: Homo sapiens (Human).

Function: Cell adhesion molecule with an important role in the development of the nervous system. Involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. Binds to axonin on neurons.

Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q05695}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q05695}. Cell projection, growth cone {ECO:0000250|UniProtKB:Q05695}. Note=Colocalized with SHTN1 in close apposition with actin filaments in filopodia and lamellipodia of axonalne growth cones of hippocampal neurons. {ECO:0000250|UniProtKB:Q05695}.

Transmembrane domains:

  1. 1121-1143, 23 AA, Helical. {ECO:0000255}.

Sequence: 1257 AA

10 20 30 40 50 60 MVVALRYVWP LLLCSPCLLI QIPEEYEGHH VMEPPVITEQ SPRRLVVFPT DDISLKCEAS 70 80 90 100 110 120 GKPEVQFRWT RDGVHFKPKE ELGVTVYQSP HSGSFTITGN NSNFAQRFQG IYRCFASNKL 130 140 150 160 170 180 GTAMSHEIRL MAEGAPKWPK ETVKPVEVEE GESVVLPCNP PPSAEPLRIY WMNSKILHIK 190 200 210 220 230 240 QDERVTMGQN GNLYFANVLT SDNHSDYICH AHFPGTRTII QKEPIDLRVK ATNSMIDRKP 250 260 270 280 290 300 RLLFPTNSSS HLVALQGQPL VLECIAEGFP TPTIKWLRPS GPMPADRVTY QNHNKTLQLL 310 320 330 340 350 360 KVGEEDDGEY RCLAENSLGS ARHAYYVTVE AAPYWLHKPQ SHLYGPGETA RLDCQVQGRP 370 380 390 400 410 420 QPEVTWRING IPVEELAKDQ KYRIQRGALI LSNVQPSDTM VTQCEARNRH GLLLANAYIY 430 440 450 460 470 480 VVQLPAKILT ADNQTYMAVQ GSTAYLLCKA FGAPVPSVQW LDEDGTTVLQ DERFFPYANG 490 500 510 520 530 540 TLGIRDLQAN DTGRYFCLAA NDQNNVTIMA NLKVKDATQI TQGPRSTIEK KGSRVTFTCQ 550 560 570 580 590 600 ASFDPSLQPS ITWRGDGRDL QELGDSDKYF IEDGRLVIHS LDYSDQGNYS CVASTELDVV 610 620 630 640 650 660 ESRAQLLVVG SPGPVPRLVL SDLHLLTQSQ VRVSWSPAED HNAPIEKYDI EFEDKEMAPE 670 680 690 700 710 720 KWYSLGKVPG NQTSTTLKLS PYVHYTFRVT AINKYGPGEP SPVSETVVTP EAAPEKNPVD 730 740 750 760 770 780 VKGEGNETTN MVITWKPLRW MDWNAPQVQY RVQWRPQGTR GPWQEQIVSD PFLVVSNTST 790 800 810 820 830 840 FVPYEIKVQA VNSQGKGPEP QVTIGYSGED YPQAIPELEG IEILNSSAVL VKWRPVDLAQ 850 860 870 880 890 900 VKGHLRGYNV TYWREGSQRK HSKRHIHKDH VVVPANTTSV ILSGLRPYSS YHLEVQAFNG 910 920 930 940 950 960 RGSGPASEFT FSTPEGVPGH PEALHLECQS NTSLLLRWQP PLSHNGVLTG YVLSYHPLDE 970 980 990 1000 1010 1020 GGKGQLSFNL RDPELRTHNL TDLSPHLRYR FQLQATTKEG PGEAIVREGG TMALSGISDF 1030 1040 1050 1060 1070 1080 GNISATAGEN YSVVSWVPKE GQCNFRFHIL FKALGEEKGG ASLSPQYVSY NQSSYTQWDL 1090 1100 1110 1120 1130 1140 QPDTDYEIHL FKERMFRHQM AVKTNGTGRV RLPPAGFATE GWFIGFVSAI ILLLLVLLIL 1150 1160 1170 1180 1190 1200 CFIKRSKGGK YSVKDKEDTQ VDSEARPMKD ETFGEYRSLE SDNEEKAFGS SQPSLNGDIK 1210 1220 1230 1240 1250 PLGSDDSLAD YGGSVDVQFN EDGSFIGQYS GKKEKEAAGG NDSSGATSPI NPAVALE

CATM prediction

The sequence of L1CAM_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
    1120      1130      1140   
  |    +    |    +    |    + 		 (Å) (°) (Å) (°)  
Model 1 ATEGWFIGFVSAIILLLLVLLILCFIKRS 6.8 -46.8° 3.9 53.0 -28.8
Model 2 ATEGWFIGFVSAIILLLLVLLILCFIKRS 7.3 -27.0° 6.0 58.0 -17.6

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 1122, TRP, HA A, 1121, GLY, O 2.73Å
B, 1125, GLY, HA1 A, 1122, TRP, O 3.00Å
B, 1122, TRP, HE1 A, 1128, SER, OG 2.13Å
A, 1122, TRP, HA B, 1121, GLY, O 2.73Å
A, 1125, GLY, HA1 B, 1122, TRP, O 3.00Å
A, 1122, TRP, HE1 B, 1128, SER, OG 2.13Å