Low affinity immunoglobulin gamma Fc region receptor II-c

UniProt data

UniProt name: FCG2C_HUMAN (P31995)

Gene name: FCGR2C; Synonyms=CD32, FCG2, IGFR2

Organism: Homo sapiens (Human).

Function: Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells.

Subcellular location: Isoform IIC1: Cell membrane; Single-pass type I membrane protein.

Transmembrane domains:

  1. 224-246, 23 AA, Helical. {ECO:0000255}.

Sequence: 323 AA

10 20 30 40 50 60 MGILSFLPVL ATESDWADCK SPQPWGHMLL WTAVLFLAPV AGTPAAPPKA VLKLEPQWIN 70 80 90 100 110 120 VLQEDSVTLT CRGTHSPESD SIQWFHNGNL IPTHTQPSYR FKANNNDSGE YTCQTGQTSL 130 140 150 160 170 180 SDPVHLTVLS EWLVLQTPHL EFQEGETIVL RCHSWKDKPL VKVTFFQNGK SKKFSRSDPN 190 200 210 220 230 240 FSIPQANHSH SGDYHCTGNI GYTLYSSKPV TITVQAPSSS PMGIIVAVVT GIAVAAIVAA 250 260 270 280 290 300 VVALIYCRKK RISANSTDPV KAAQFEPPGR QMIAIRKRQP EETNNDYETA DGGYMTLNPR 310 320 APTDDDKNIY LTLPPNDHVN SNN

CATM prediction

The sequence of FCG2C_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
           230       240       
    +    |    +    |    +    		 (Å) (°) (Å) (°)  
Model 1 AMGIIVAVVTGIAVAAIVAAVVALIYCRK 7.0 -46.2° 2.7 47.3 -30.8
Model 2 AMGIIVAVVTGIAVAAIVAAVVALIYCRK 7.2 -37.2° 2.3 35.9 -2.8
Prolines* PMGIIVAVVTGIAVAAIVAAVVALIYCRK          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 228, VAL, HA A, 227, ALA, O 2.85Å
B, 231, GLY, HA1 A, 228, VAL, O 2.77Å
B, 232, ILE, HA A, 231, GLY, O 3.31Å
A, 228, VAL, HA B, 227, ALA, O 2.85Å
A, 231, GLY, HA1 B, 228, VAL, O 2.77Å
A, 232, ILE, HA B, 231, GLY, O 3.31Å