UniProt data
UniProt name: SDC4_HUMAN (P31431)
Gene name: SDC4
Organism: Homo sapiens (Human).
Function: Cell surface proteoglycan that bears heparan sulfate. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP (PubMed:22660413). {ECO:0000269|PubMed:22660413}.
Subcellular location: Isoform 2: Secreted.
Transmembrane domains:
- 146-170, 25 AA, Helical. {ECO:0000255}.
Sequence: 198 AA
10 20 30 40 50 60
MAPARLFALL LFFVGGVAES IRETEVIDPQ DLLEGRYFSG ALPDDEDVVG PGQESDDFEL
70 80 90 100 110 120
SGSGDLDDLE DSMIGPEVVH PLVPLDNHIP ERAGSGSQVP TEPKKLEENE VIPKRISPVE
130 140 150 160 170 180
ESEDVSNKVS MSSTVQGSNI FERTEVLAAL IVGGIVGILF AVFLILLLMY RMKKKDEGSY
190
DLGKKPIYKK APTNEFYA
CATM prediction
The sequence of SDC4_HUMAN returned 5 potential models
The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.
| # | Sequence and interface | d | θ | Z' | ω' | Score |
|---|---|---|---|---|---|---|
| 150 160 170 + | + | + | |
(Å) | (°) | (Å) | (°) | ||
| Model 1 | RTEVLAALIVGGIVGILFAVFLILLLMYRMK | 6.5 | -39.0° | 6.0 | 44.8 | -43.3 |
| Model 2 | RTEVLAALIVGGIVGILFAVFLILLLMYRMK | 6.4 | -54.7° | 4.9 | 52.8 | -29.0 |
| Model 3 | RTEVLAALIVGGIVGILFAVFLILLLMYRMK | 6.7 | -51.9° | 1.3 | 57.0 | -26.4 |
| Model 4 | RTEVLAALIVGGIVGILFAVFLILLLMYRMK | 7.2 | -34.3° | 2.7 | 37.4 | -21.4 |
| Model 5 | RTEVLAALIVGGIVGILFAVFLILLLMYRMK | 7.3 | -47.0° | 3.3 | 54.2 | -13.3 |
Click on the model number to visualize its details below.
MODEL 1 DETAILS
Precited structure:
Click on the image to enlarge
Download model 1 structure: PDB, PyMOL session
List of hydrogen bonds:
| Donor | Acceptor | Distance |
|---|---|---|
| B, 150, LEU, HA | A, 149, ALA, O | 3.12Å |
| B, 153, GLY, HA1 | A, 150, LEU, O | 2.67Å |
| B, 154, GLY, HA2 | A, 153, GLY, O | 2.41Å |
| B, 157, GLY, HA1 | A, 154, GLY, O | 3.09Å |
| A, 150, LEU, HA | B, 149, ALA, O | 3.12Å |
| A, 153, GLY, HA1 | B, 150, LEU, O | 2.67Å |
| A, 154, GLY, HA2 | B, 153, GLY, O | 2.41Å |
| A, 157, GLY, HA1 | B, 154, GLY, O | 3.09Å |
