Tyrosine-protein kinase receptor UFO

UniProt data

UniProt name: UFO_HUMAN (P30530)

Gene name: AXL; Synonyms=UFO

Organism: Homo sapiens (Human).

Function: (Microbial infection) Acts as a receptor for lassa virus and lymphocytic choriomeningitis virus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope (PubMed:22156524, PubMed:22673088, PubMed:25277499, PubMed:21501828). Acts as a receptor for ebolavirus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope (PubMed:17005688). {ECO:0000269|PubMed:17005688, ECO:0000269|PubMed:21501828, ECO:0000269|PubMed:22156524, ECO:0000269|PubMed:22673088, ECO:0000269|PubMed:25277499}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:7896447}; Single-pass type I membrane protein {ECO:0000269|PubMed:7896447}.

Transmembrane domains:

  1. 452-472, 21 AA, Helical. {ECO:0000255}.

Sequence: 894 AA

10 20 30 40 50 60 MAWRCPRMGR VPLAWCLALC GWACMAPRGT QAEESPFVGN PGNITGARGL TGTLRCQLQV 70 80 90 100 110 120 QGEPPEVHWL RDGQILELAD STQTQVPLGE DEQDDWIVVS QLRITSLQLS DTGQYQCLVF 130 140 150 160 170 180 LGHQTFVSQP GYVGLEGLPY FLEEPEDRTV AANTPFNLSC QAQGPPEPVD LLWLQDAVPL 190 200 210 220 230 240 ATAPGHGPQR SLHVPGLNKT SSFSCEAHNA KGVTTSRTAT ITVLPQQPRN LHLVSRQPTE 250 260 270 280 290 300 LEVAWTPGLS GIYPLTHCTL QAVLSNDGMG IQAGEPDPPE EPLTSQASVP PHQLRLGSLH 310 320 330 340 350 360 PHTPYHIRVA CTSSQGPSSW THWLPVETPE GVPLGPPENI SATRNGSQAF VHWQEPRAPL 370 380 390 400 410 420 QGTLLGYRLA YQGQDTPEVL MDIGLRQEVT LELQGDGSVS NLTVCVAAYT AAGDGPWSLP 430 440 450 460 470 480 VPLEAWRPGQ AQPVHQLVKE PSTPAFSWPW WYVLLGAVVA AACVLILALF LVHRRKKETR 490 500 510 520 530 540 YGEVFEPTVE RGELVVRYRV RKSYSRRTTE ATLNSLGISE ELKEKLRDVM VDRHKVALGK 550 560 570 580 590 600 TLGEGEFGAV MEGQLNQDDS ILKVAVKTMK IAICTRSELE DFLSEAVCMK EFDHPNVMRL 610 620 630 640 650 660 IGVCFQGSER ESFPAPVVIL PFMKHGDLHS FLLYSRLGDQ PVYLPTQMLV KFMADIASGM 670 680 690 700 710 720 EYLSTKRFIH RDLAARNCML NENMSVCVAD FGLSKKIYNG DYYRQGRIAK MPVKWIAIES 730 740 750 760 770 780 LADRVYTSKS DVWSFGVTMW EIATRGQTPY PGVENSEIYD YLRQGNRLKQ PADCLDGLYA 790 800 810 820 830 840 LMSRCWELNP QDRPSFTELR EDLENTLKAL PPAQEPDEIL YVNMDEGGGY PEPPGAAGGA 850 860 870 880 890 DPPTQPDPKD SCSCLTAAEV HPAGRYVLCP STTPSPAQPA DRGSPAAPGQ EDGA

CATM prediction

The sequence of UFO_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
   450       460       470   
 |    +    |    +    |    +		 (Å) (°) (Å) (°)  
Model 1 AWWYVLLGAVVAAACVLILALFLVHRR 6.9 -47.0° 2.3 44.9 -19.7
Prolines* PWWYVLLGAVVAAACVLILALFLVHRR          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 453, VAL, HA A, 452, TYR, O 2.99Å
B, 456, GLY, HA1 A, 453, VAL, O 2.74Å
B, 457, ALA, HA A, 456, GLY, O 3.16Å
A, 453, VAL, HA B, 452, TYR, O 2.99Å
A, 456, GLY, HA1 B, 453, VAL, O 2.74Å
A, 457, ALA, HA B, 456, GLY, O 3.16Å