HLA class I histocompatibility antigen, A-74 alpha chain

UniProt data

UniProt name: 1A74_HUMAN (P30459)

Gene name: HLA-A; Synonyms=HLAA

Organism: Homo sapiens (Human).

Function: Involved in the presentation of foreign antigens to the immune system.

Subcellular location: Membrane; Single-pass type I membrane protein.

Transmembrane domains:

  1. 309-332, 24 AA, Helical. {ECO:0000255}.

Sequence: 365 AA

10 20 30 40 50 60 MAVMAPRTLL LLLLGALALT QTRAGSHSMR YFFTSVSRPG RGEPRFIAVG YVDDTQFVRF 70 80 90 100 110 120 DSDAASQRME PRAPWIEQEG PEYWDQETRN VKAHSQTDRV DLGTLRGYYN QSEAGSHTIQ 130 140 150 160 170 180 MMYGCDVGPD GRLLRGYQQD AYDGKDYIAL NEDLRSWTAA DMAAQITQRK WEAARVAEQL 190 200 210 220 230 240 RAYLEGTCVE WLRRYLENGK ETLQRTDAPK THMTHHAVSD HEATLRCWAL SFYPAEITLT 250 260 270 280 290 300 WQRDGEDQTQ DTELVETRPA GDGTFQKWAS VVVPSGQEQR YTCHVQHEGL PKPLTLRWEP 310 320 330 340 350 360 SSQPTIPIVG IIAGLVLFGA MFAGAVVAAV RWRRKSSDRK GGSYSQAASS DSAQGSDMSL TACKV

CATM prediction

The sequence of 1A74_HUMAN returned 3 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
      310       320       330   
    |    +    |    +    |    +		 (Å) (°) (Å) (°)  
Model 1 IAIVGIIAGLVLFGAMFAGAVVAAVRWRRK 7.3 -47.9° 0.5 46.3 -31.7
Model 2 IAIVGIIAGLVLFGAMFAGAVVAAVRWRRK 6.9 -51.0° 1.2 45.0 -16.1
Model 3 IAIVGIIAGLVLFGAMFAGAVVAAVRWRRK 6.8 -44.0° 1.8 44.9 -12.0
Prolines* IPIVGIIAGLVLFGAMFAGAVVAAVRWRRK          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 319, GLY, HA1 A, 316, VAL, O 3.25Å
B, 320, ALA, HA A, 319, GLY, O 3.23Å
A, 319, GLY, HA1 B, 316, VAL, O 3.25Å
A, 320, ALA, HA B, 319, GLY, O 3.23Å