UniProt data
UniProt name: 1A23_HUMAN (P30447)
Gene name: HLA-A; Synonyms=HLAA
Organism: Homo sapiens (Human).
Function: Involved in the presentation of foreign antigens to the immune system.
Subcellular location: Membrane; Single-pass type I membrane protein.
Transmembrane domains:
- 309-332, 24 AA, Helical. {ECO:0000255}.
Sequence: 365 AA
10 20 30 40 50 60
MAVMAPRTLV LLLSGALALT QTWAGSHSMR YFSTSVSRPG RGEPRFIAVG YVDDTQFVRF
70 80 90 100 110 120
DSDAASQRME PRAPWIEQEG PEYWDEETGK VKAHSQTDRE NLRIALRYYN QSEAGSHTLQ
130 140 150 160 170 180
MMFGCDVGSD GRFLRGYHQY AYDGKDYIAL KEDLRSWTAA DMAAQITQRK WEAARVAEQL
190 200 210 220 230 240
RAYLEGTCVD GLRRYLENGK ETLQRTDPPK THMTHHPISD HEATLRCWAL GFYPAEITLT
250 260 270 280 290 300
WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP
310 320 330 340 350 360
SSQPTVHIVG IIAGLVLLGA VITGAVVAAV MWRRNSSDRK GGSYSQAASS DSAQGSDVSL
TACKV
CATM prediction
The sequence of 1A23_HUMAN returned 3 potential models
The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.
| # | Sequence and interface | d | θ | Z' | ω' | Score |
|---|---|---|---|---|---|---|
| 310 320 330 | + | + | + |
(Å) | (°) | (Å) | (°) | ||
| Model 1 | VHIVGIIAGLVLLGAVITGAVVAAVMWRRN | 6.7 | -47.0° | 1.4 | 45.0 | -23.8 |
| Model 2 | VHIVGIIAGLVLLGAVITGAVVAAVMWRRN | 7.2 | -53.0° | 2.0 | 44.8 | -6.5 |
| Model 3 | VHIVGIIAGLVLLGAVITGAVVAAVMWRRN | 7.3 | -55.0° | 0.3 | 45.0 | -5.5 |
Click on the model number to visualize its details below.
MODEL 1 DETAILS
Precited structure:
Click on the image to enlarge
Download model 1 structure: PDB, PyMOL session
List of hydrogen bonds:
| Donor | Acceptor | Distance |
|---|---|---|
| B, 321, VAL, HA | A, 320, ALA, O | 3.05Å |
| B, 324, GLY, HA1 | A, 321, VAL, O | 2.66Å |
| B, 325, ALA, HA | A, 324, GLY, O | 2.93Å |
| A, 321, VAL, HA | B, 320, ALA, O | 3.05Å |
| A, 324, GLY, HA1 | B, 321, VAL, O | 2.66Å |
| A, 325, ALA, HA | B, 324, GLY, O | 2.93Å |
