CD40 ligand

UniProt data

UniProt name: CD40L_HUMAN (P29965)

Gene name: CD40LG; Synonyms=CD40L, TNFSF5, TRAP

Organism: Homo sapiens (Human).

Function: Release of soluble CD40L from platelets is partially regulated by GP IIb/IIIa, actin polymerization, and an matrix metalloproteinases (MMP) inhibitor-sensitive pathway. {ECO:0000269|PubMed:15193700}.

Subcellular location: CD40 ligand, soluble form: Secreted {ECO:0000269|PubMed:8626375}.

Transmembrane domains:

  1. 23-46, 24 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.

Sequence: 261 AA

10 20 30 40 50 60 MIETYNQTSP RSAATGLPIS MKIFMYLLTV FLITQMIGSA LFAVYLHRRL DKIEDERNLH 70 80 90 100 110 120 EDFVFMKTIQ RCNTGERSLS LLNCEEIKSQ FEGFVKDIML NKEETKKENS FEMQKGDQNP 130 140 150 160 170 180 QIAAHVISEA SSKTTSVLQW AEKGYYTMSN NLVTLENGKQ LTVKRQGLYY IYAQVTFCSN 190 200 210 220 230 240 REASSQAPFI ASLCLKSPGR FERILLRAAN THSSAKPCGQ QSIHLGGVFE LQPGASVFVN 250 260 VTDPSQVSHG TGFTSFGLLK L

CATM prediction

The sequence of CD40L_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
  20        30        40        
|    +    |    +    |    +    		 (Å) (°) (Å) (°)  
Model 1 SMKIFMYLLTVFLITQMIGSALFAVYLHRR 7.0 -53.0° 1.9 45.5 -20.4

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 35, GLN, HA A, 34, THR, O 3.05Å
B, 38, GLY, HA1 A, 35, GLN, O 2.75Å
A, 35, GLN, HA B, 34, THR, O 3.05Å
A, 38, GLY, HA1 B, 35, GLN, O 2.75Å