Hematopoietic progenitor cell antigen CD34

UniProt data

UniProt name: CD34_HUMAN (P28906)

Gene name: CD34

Organism: Homo sapiens (Human).

Function: Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins.

Subcellular location: Membrane; Single-pass type I membrane protein.

Transmembrane domains:

  1. 291-311, 21 AA, Helical. {ECO:0000255}.

Sequence: 385 AA

10 20 30 40 50 60 MLVRRGARAG PRMPRGWTAL CLLSLLPSGF MSLDNNGTAT PELPTQGTFS NVSTNVSYQE 70 80 90 100 110 120 TTTPSTLGST SLHPVSQHGN EATTNITETT VKFTSTSVIT SVYGNTNSSV QSQTSVISTV 130 140 150 160 170 180 FTTPANVSTP ETTLKPSLSP GNVSDLSTTS TSLATSPTKP YTSSSPILSD IKAEIKCSGI 190 200 210 220 230 240 REVKLTQGIC LEQNKTSSCA EFKKDRGEGL ARVLCGEEQA DADAGAQVCS LLLAQSEVRP 250 260 270 280 290 300 QCLLLVLANR TEISSKLQLM KKHQSDLKKL GILDFTEQDV ASHQSYSQKT LIALVTSGAL 310 320 330 340 350 360 LAVLGITGYF LMNRRSWSPT GERLGEDPYY TENGGGQGYS SGPGTSPEAQ GKASVNRGAQ 370 380 ENGTGQATSR NGHSARQHVV ADTEL

CATM prediction

The sequence of CD34_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
    290       300       310  
  |    +    |    +    |    		 (Å) (°) (Å) (°)  
Model 1 QKTLIALVTSGALLAVLGITGYFLMNR 7.4 -53.9° 3.6 35.1 -20.2
Model 2 QKTLIALVTSGALLAVLGITGYFLMNR 6.8 -55.5° 0.9 50.1 -17.1

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 302, ALA, HA A, 301, LEU, O 3.38Å
B, 305, GLY, HA1 A, 302, ALA, O 3.36Å
A, 302, ALA, HA B, 301, LEU, O 3.38Å
A, 305, GLY, HA1 B, 302, ALA, O 3.36Å