Receptor-type tyrosine-protein phosphatase mu

UniProt data

UniProt name: PTPRM_HUMAN (P28827)

Gene name: PTPRM; Synonyms=PTPRL1

Organism: Homo sapiens (Human).

Function: Involved in cell-cell adhesion through homophilic interactions. May play a key role in signal transduction and growth control. {ECO:0000269|PubMed:16456543}.

Subcellular location: Membrane; Single-pass type I membrane protein.

Transmembrane domains:

  1. 743-764, 22 AA, Helical. {ECO:0000255}.

Sequence: 1452 AA

10 20 30 40 50 60 MRGLGTCLAT LAGLLLTAAG ETFSGGCLFD EPYSTCGYSQ SEGDDFNWEQ VNTLTKPTSD 70 80 90 100 110 120 PWMPSGSFML VNASGRPEGQ RAHLLLPQLK ENDTHCIDFH YFVSSKSNSP PGLLNVYVKV 130 140 150 160 170 180 NNGPLGNPIW NISGDPTRTW NRAELAISTF WPNFYQVIFE VITSGHQGYL AIDEVKVLGH 190 200 210 220 230 240 PCTRTPHFLR IQNVEVNAGQ FATFQCSAIG RTVAGDRLWL QGIDVRDAPL KEIKVTSSRR 250 260 270 280 290 300 FIASFNVVNT TKRDAGKYRC MIRTEGGVGI SNYAELVVKE PPVPIAPPQL ASVGATYLWI 310 320 330 340 350 360 QLNANSINGD GPIVAREVEY CTASGSWNDR QPVDSTSYKI GHLDPDTEYE ISVLLTRPGE 370 380 390 400 410 420 GGTGSPGPAL RTRTKCADPM RGPRKLEVVE VKSRQITIRW EPFGYNVTRC HSYNLTVHYC 430 440 450 460 470 480 YQVGGQEQVR EEVSWDTENS HPQHTITNLS PYTNVSVKLI LMNPEGRKES QELIVQTDED 490 500 510 520 530 540 LPGAVPTESI QGSTFEEKIF LQWREPTQTY GVITLYEITY KAVSSFDPEI DLSNQSGRVS 550 560 570 580 590 600 KLGNETHFLF FGLYPGTTYS FTIRASTAKG FGPPATNQFT TKISAPSMPA YELETPLNQT 610 620 630 640 650 660 DNTVTVMLKP AHSRGAPVSV YQIVVEEERP RRTKKTTEIL KCYPVPIHFQ NASLLNSQYY 670 680 690 700 710 720 FAAEFPADSL QAAQPFTIGD NKTYNGYWNT PLLPYKSYRI YFQAASRANG ETKIDCVQVA 730 740 750 760 770 780 TKGAATPKPV PEPEKQTDHT VKIAGVIAGI LLFVIIFLGV VLVMKKRKLA KKRKETMSST 790 800 810 820 830 840 RQEMTVMVNS MDKSYAEQGT NCDEAFSFMD THNLNGRSVS SPSSFTMKTN TLSTSVPNSY 850 860 870 880 890 900 YPDETHTMAS DTSSLVQSHT YKKREPADVP YQTGQLHPAI RVADLLQHIT QMKCAEGYGF 910 920 930 940 950 960 KEEYESFFEG QSAPWDSAKK DENRMKNRYG NIIAYDHSRV RLQTIEGDTN SDYINGNYID 970 980 990 1000 1010 1020 GYHRPNHYIA TQGPMQETIY DFWRMVWHEN TASIIMVTNL VEVGRVKCCK YWPDDTEIYK 1030 1040 1050 1060 1070 1080 DIKVTLIETE LLAEYVIRTF AVEKRGVHEI REIRQFHFTG WPDHGVPYHA TGLLGFVRQV 1090 1100 1110 1120 1130 1140 KSKSPPSAGP LVVHCSAGAG RTGCFIVIDI MLDMAEREGV VDIYNCVREL RSRRVNMVQT 1150 1160 1170 1180 1190 1200 EEQYVFIHDA ILEACLCGDT SVPASQVRSL YYDMNKLDPQ TNSSQIKEEF RTLNMVTPTL 1210 1220 1230 1240 1250 1260 RVEDCSIALL PRNHEKNRCM DILPPDRCLP FLITIDGESS NYINAALMDS YKQPSAFIVT 1270 1280 1290 1300 1310 1320 QHPLPNTVKD FWRLVLDYHC TSVVMLNDVD PAQLCPQYWP ENGVHRHGPI QVEFVSADLE 1330 1340 1350 1360 1370 1380 EDIISRIFRI YNAARPQDGY RMVQQFQFLG WPMYRDTPVS KRSFLKLIRQ VDKWQEEYNG 1390 1400 1410 1420 1430 1440 GEGRTVVHCL NGGGRSGTFC AISIVCEMLR HQRTVDVFHA VKTLRNNKPN MVDLLDQYKF 1450 CYEVALEYLN SG

CATM prediction

The sequence of PTPRM_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
  740       750       760     
|    +    |    +    |    +  		 (Å) (°) (Å) (°)  
Model 1 TVKIAGVIAGILLFVIIFLGVVLVMKKR 6.9 -54.3° 3.6 49.3 -17.4
Model 2 TVKIAGVIAGILLFVIIFLGVVLVMKKR 7.4 -41.0° 3.5 38.0 -11.3

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 746, VAL, HA A, 745, GLY, O 2.89Å
B, 749, GLY, HA1 A, 746, VAL, O 3.02Å
A, 746, VAL, HA B, 745, GLY, O 2.89Å
A, 749, GLY, HA1 B, 746, VAL, O 3.02Å