HLA class II histocompatibility antigen, DM alpha chain

UniProt data

UniProt name: DMA_HUMAN (P28067)

Gene name: HLA-DMA; Synonyms=DMA, RING6

Organism: Homo sapiens (Human).

Function: Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. {ECO:0000269|PubMed:16547258, ECO:0000269|PubMed:8849454, ECO:0000269|PubMed:9768757}.

Subcellular location: Late endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=Localizes to late endocytic compartment. Associates with lysosome membranes.

Transmembrane domains:

  1. 234-254, 21 AA, Helical. {ECO:0000255}.

Sequence: 261 AA

10 20 30 40 50 60 MGHEQNQGAA LLQMLPLLWL LPHSWAVPEA PTPMWPDDLQ NHTFLHTVYC QDGSPSVGLS 70 80 90 100 110 120 EAYDEDQLFF FDFSQNTRVP RLPEFADWAQ EQGDAPAILF DKEFCEWMIQ QIGPKLDGKI 130 140 150 160 170 180 PVSRGFPIAE VFTLKPLEFG KPNTLVCFVS NLFPPMLTVN WHDHSVPVEG FGPTFVSAVD 190 200 210 220 230 240 GLSFQAFSYL NFTPEPSDIF SCIVTHEIDR YTAIAYWVPR NALPSDLLEN VLCGVAFGLG 250 260 VLGIIVGIVL IIYFRKPCSG D

CATM prediction

The sequence of DMA_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
           240       250     
    +    |    +    |    +  		 (Å) (°) (Å) (°)  
Model 1 VLCGVAFGLGVLGIIVGIVLIIYFRKA 7.0 -46.9° 1.3 45.3 -23.5
Prolines* VLCGVAFGLGVLGIIVGIVLIIYFRKP          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 240, GLY, HA2 A, 239, LEU, O 3.44Å
B, 243, GLY, HA1 A, 240, GLY, O 3.01Å
B, 244, ILE, HA A, 243, GLY, O 3.07Å
A, 240, GLY, HA2 B, 239, LEU, O 3.44Å
A, 243, GLY, HA1 B, 240, GLY, O 3.01Å
A, 244, ILE, HA B, 243, GLY, O 3.07Å