Interleukin-1 receptor type 2

UniProt data

UniProt name: IL1R2_HUMAN (P27930)

Gene name: IL1R2; Synonyms=IL1RB

Organism: Homo sapiens (Human).

Function: Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. {ECO:0000269|PubMed:10975853, ECO:0000269|PubMed:12530978, ECO:0000269|PubMed:7989776, ECO:0000269|PubMed:9862719}.

Subcellular location: Isoform Long: Cell membrane; Single-pass type I membrane protein.

Transmembrane domains:

  1. 344-369, 26 AA, Helical. {ECO:0000255}.

Sequence: 398 AA

10 20 30 40 50 60 MLRLYVLVMG VSAFTLQPAA HTGAARSCRF RGRHYKREFR LEGEPVALRC PQVPYWLWAS 70 80 90 100 110 120 VSPRINLTWH KNDSARTVPG EEETRMWAQD GALWLLPALQ EDSGTYVCTT RNASYCDKMS 130 140 150 160 170 180 IELRVFENTD AFLPFISYPQ ILTLSTSGVL VCPDLSEFTR DKTDVKIQWY KDSLLLDKDN 190 200 210 220 230 240 EKFLSVRGTT HLLVHDVALE DAGYYRCVLT FAHEGQQYNI TRSIELRIKK KKEETIPVII 250 260 270 280 290 300 SPLKTISASL GSRLTIPCKV FLGTGTPLTT MLWWTANDTH IESAYPGGRV TEGPRQEYSE 310 320 330 340 350 360 NNENYIEVPL IFDPVTREDL HMDFKCVVHN TLSFQTLRTT VKEASSTFSW GIVLAPLSLA 370 380 390 FLVLGGIWMH RRCKHRTGKA DGLTVLWPHH QDFQSYPK

CATM prediction

The sequence of IL1R2_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
           350       360       370
    +    |    +    |    +    |  		 (Å) (°) (Å) (°)  
Model 1 VKEASSTFSWGIVLAALSLAFLVLGGIWMHRR 7.2 -39.9° 2.7 34.0 -7.1
Model 2 VKEASSTFSWGIVLAALSLAFLVLGGIWMHRR 6.4 -55.0° 1.5 44.8 -6.8
Prolines* VKEASSTFSWGIVLAPLSLAFLVLGGIWMHRR          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 362, LEU, HA A, 361, PHE, O 3.47Å
B, 365, GLY, HA1 A, 362, LEU, O 3.29Å
A, 362, LEU, HA B, 361, PHE, O 3.47Å
A, 365, GLY, HA1 B, 362, LEU, O 3.29Å