Activin receptor type-2A

UniProt data

UniProt name: AVR2A_HUMAN (P27037)

Gene name: ACVR2A; Synonyms=ACVR2

Organism: Homo sapiens (Human).

Function: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. Mediates induction of adipogenesis by GDF6 (By similarity). {ECO:0000250|UniProtKB:P27038, ECO:0000269|PubMed:1314589}.

Subcellular location: Membrane; Single-pass type I membrane protein.

Transmembrane domains:

  1. 136-161, 26 AA, Helical. {ECO:0000255}.

Sequence: 513 AA

10 20 30 40 50 60 MGAAAKLAFA VFLISCSSGA ILGRSETQEC LFFNANWEKD RTNQTGVEPC YGDKDKRRHC 70 80 90 100 110 120 FATWKNISGS IEIVKQGCWL DDINCYDRTD CVEKKDSPEV YFCCCEGNMC NEKFSYFPEM 130 140 150 160 170 180 EVTQPTSNPV TPKPPYYNIL LYSLVPLMLI AGIVICAFWV YRHHKMAYPP VLVPTQDPGP 190 200 210 220 230 240 PPPSPLLGLK PLQLLEVKAR GRFGCVWKAQ LLNEYVAVKI FPIQDKQSWQ NEYEVYSLPG 250 260 270 280 290 300 MKHENILQFI GAEKRGTSVD VDLWLITAFH EKGSLSDFLK ANVVSWNELC HIAETMARGL 310 320 330 340 350 360 AYLHEDIPGL KDGHKPAISH RDIKSKNVLL KNNLTACIAD FGLALKFEAG KSAGDTHGQV 370 380 390 400 410 420 GTRRYMAPEV LEGAINFQRD AFLRIDMYAM GLVLWELASR CTAADGPVDE YMLPFEEEIG 430 440 450 460 470 480 QHPSLEDMQE VVVHKKKRPV LRDYWQKHAG MAMLCETIEE CWDHDAEARL SAGCVGERIT 490 500 510 QMQRLTNIIT TEDIVTVVTM VTNVDFPPKE SSL

CATM prediction

The sequence of AVR2A_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
         140       150       160  
  +    |    +    |    +    |    		 (Å) (°) (Å) (°)  
Model 1 KAAYYNILLYSLVALMLIAGIVICAFWVYRHH 7.3 -47.0° 1.3 45.1 -28.9
Prolines* KPPYYNILLYSLVPLMLIAGIVICAFWVYRHH          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 152, GLY, HA1 A, 149, LEU, O 3.26Å
B, 153, ILE, HA A, 152, GLY, O 3.42Å
A, 152, GLY, HA1 B, 149, LEU, O 3.26Å
A, 153, ILE, HA B, 152, GLY, O 3.42Å