3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2

UniProt data

UniProt name: 3BHS2_HUMAN (P26439)

Gene name: HSD3B2; Synonyms=HSDB3B

Organism: Homo sapiens (Human).

Function: 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids.

Subcellular location: Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein.

Transmembrane domains:

  1. 287-307, 21 AA, Helical. {ECO:0000255}.

Sequence: 372 AA

10 20 30 40 50 60 MGWSCLVTGA GGLLGQRIVR LLVEEKELKE IRALDKAFRP ELREEFSKLQ NRTKLTVLEG 70 80 90 100 110 120 DILDEPFLKR ACQDVSVVIH TACIIDVFGV THRESIMNVN VKGTQLLLEA CVQASVPVFI 130 140 150 160 170 180 YTSSIEVAGP NSYKEIIQNG HEEEPLENTW PTPYPYSKKL AEKAVLAANG WNLKNGDTLY 190 200 210 220 230 240 TCALRPTYIY GEGGPFLSAS INEALNNNGI LSSVGKFSTV NPVYVGNVAW AHILALRALR 250 260 270 280 290 300 DPKKAPSVRG QFYYISDDTP HQSYDNLNYI LSKEFGLRLD SRWSLPLTLM YWIGFLLEVV 310 320 330 340 350 360 SFLLSPIYSY QPPFNRHTVT LSNSVFTFSY KKAQRDLAYK PLYSWEEAKQ KTVEWVGSLV 370 DRHKETLKSK TQ

CATM prediction

The sequence of 3BHS2_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
        290       300       3
 +    |    +    |    +    |		 (Å) (°) (Å) (°)  
Model 1 SLALTLMYWIGFLLEVVSFLLSAIYSY 7.4 -53.9° 2.9 51.1 -2.6
Prolines* SLPLTLMYWIGFLLEVVSFLLSPIYSY          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 291, TYR, HA A, 290, MET, O 3.47Å
B, 294, GLY, HA1 A, 291, TYR, O 3.41Å
A, 291, TYR, HA B, 290, MET, O 3.47Å
A, 294, GLY, HA1 B, 291, TYR, O 3.41Å