Integrin beta-7

UniProt data

UniProt name: ITB7_HUMAN (P26010)

Gene name: ITGB7

Organism: Homo sapiens (Human).

Function: Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin alpha-4/beta-7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Interacts also with VCAM1 and fibronectin, an extracellular matrix component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Interactions involves the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin. Binds to HIV-1 gp120, thereby allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp120. Integrin alpha-E/beta-7 (HML-1) is a receptor for E-cadherin.

Subcellular location: Membrane; Single-pass type I membrane protein.

Transmembrane domains:

  1. 724-746, 23 AA, Helical. {ECO:0000255}.

Sequence: 798 AA

10 20 30 40 50 60 MVALPMVLVL LLVLSRGESE LDAKIPSTGD ATEWRNPHLS MLGSCQPAPS CQKCILSHPS 70 80 90 100 110 120 CAWCKQLNFT ASGEAEARRC ARREELLARG CPLEELEEPR GQQEVLQDQP LSQGARGEGA 130 140 150 160 170 180 TQLAPQRVRV TLRPGEPQQL QVRFLRAEGY PVDLYYLMDL SYSMKDDLER VRQLGHALLV 190 200 210 220 230 240 RLQEVTHSVR IGFGSFVDKT VLPFVSTVPS KLRHPCPTRL ERCQSPFSFH HVLSLTGDAQ 250 260 270 280 290 300 AFEREVGRQS VSGNLDSPEG GFDAILQAAL CQEQIGWRNV SRLLVFTSDD TFHTAGDGKL 310 320 330 340 350 360 GGIFMPSDGH CHLDSNGLYS RSTEFDYPSV GQVAQALSAA NIQPIFAVTS AALPVYQELS 370 380 390 400 410 420 KLIPKSAVGE LSEDSSNVVQ LIMDAYNSLS STVTLEHSSL PPGVHISYES QCEGPEKREG 430 440 450 460 470 480 KAEDRGQCNH VRINQTVTFW VSLQATHCLP EPHLLRLRAL GFSEELIVEL HTLCDCNCSD 490 500 510 520 530 540 TQPQAPHCSD GQGHLQCGVC SCAPGRLGRL CECSVAELSS PDLESGCRAP NGTGPLCSGK 550 560 570 580 590 600 GHCQCGRCSC SGQSSGHLCE CDDASCERHE GILCGGFGRC QCGVCHCHAN RTGRACECSG 610 620 630 640 650 660 DMDSCISPEG GLCSGHGRCK CNRCQCLDGY YGALCDQCPG CKTPCERHRD CAECGAFRTG 670 680 690 700 710 720 PLATNCSTAC AHTNVTLALA PILDDGWCKE RTLDNQLFFF LVEDDARGTV VLRVRPQEKG 730 740 750 760 770 780 ADHTQAIVLG CVGGIVAVGL GLVLAYRLSV EIYDRREYSR FEKEQQQLNW KQDSNPLYKS 790 AITTTINPRF QEADSPTL

CATM prediction

The sequence of ITB7_HUMAN returned 4 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
           730       740       
    +    |    +    |    +    		 (Å) (°) (Å) (°)  
Model 1 ADHTQAIVLGCVGGIVAVGLGLVLAYRLS 6.5 -47.8° 0.7 54.4 -30.9
Model 2 ADHTQAIVLGCVGGIVAVGLGLVLAYRLS 7.2 -43.1° 3.5 49.9 -21.1
Model 3 ADHTQAIVLGCVGGIVAVGLGLVLAYRLS 7.3 -35.8° 1.5 36.1 -20.0
Model 4 ADHTQAIVLGCVGGIVAVGLGLVLAYRLS 6.6 -52.0° 0.6 48.2 -16.3

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 727, ILE, HA A, 726, ALA, O 3.10Å
B, 730, GLY, HA1 A, 727, ILE, O 2.64Å
B, 731, CYS, HA A, 730, GLY, O 2.70Å
A, 727, ILE, HA B, 726, ALA, O 3.10Å
A, 730, GLY, HA1 B, 727, ILE, O 2.64Å
A, 731, CYS, HA B, 730, GLY, O 2.70Å