Tumor necrosis factor receptor superfamily member 5

UniProt data

UniProt name: TNR5_HUMAN (P25942)

Gene name: CD40; Synonyms=TNFRSF5

Organism: Homo sapiens (Human).

Function: Receptor for TNFSF5/CD40LG. Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion.

Subcellular location: Isoform II: Secreted.

Transmembrane domains:

  1. 194-215, 22 AA, Helical. {ECO:0000255}.

Sequence: 277 AA

10 20 30 40 50 60 MVRLPLQCVL WGCLLTAVHP EPPTACREKQ YLINSQCCSL CQPGQKLVSD CTEFTETECL 70 80 90 100 110 120 PCGESEFLDT WNRETHCHQH KYCDPNLGLR VQQKGTSETD TICTCEEGWH CTSEACESCV 130 140 150 160 170 180 LHRSCSPGFG VKQIATGVSD TICEPCPVGF FSNVSSAFEK CHPWTSCETK DLVVQQAGTN 190 200 210 220 230 240 KTDVVCGPQD RLRALVVIPI IFGILFAILL VLVFIKKVAK KPTNKAPHPK QEPQEINFPD 250 260 270 DLPGSNTAAP VQETLHGCQP VTQEDGKESR ISVQERQ

CATM prediction

The sequence of TNR5_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
           200       210      
    +    |    +    |    +   		 (Å) (°) (Å) (°)  
Model 1 RLRALVVIAIIFGILFAILLVLVFIKKV 6.8 -46.0° 2.7 47.0 -26.6
Prolines* RLRALVVIPIIFGILFAILLVLVFIKKV          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 200, ILE, HA A, 199, ALA, O 2.86Å
B, 203, GLY, HA1 A, 200, ILE, O 2.79Å
B, 204, ILE, HA A, 203, GLY, O 3.37Å
A, 200, ILE, HA B, 199, ALA, O 2.86Å
A, 203, GLY, HA1 B, 200, ILE, O 2.79Å
A, 204, ILE, HA B, 203, GLY, O 3.37Å